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      National scientific medical meeting 1995 abstracts : Oral presentations

      abstract
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      Irish Journal of Medical Science
      Springer-Verlag
      Acquire Immune Deficiency Syndrome, Coeliac Disease, Methicillin Resistant Staphylococcus Aureus, Graft Versus Host Disease, Irish Journal

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          Miniaturized total chemical analysis systems: A novel concept for chemical sensing

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            Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications.

            Receptors for the Fc domain of IgG (Fc gamma R) provide a critical link between specific humoral responses and the cellular branch of the immune system. When hFc gamma R interact with immunoglobulin, a variety of biological responses are triggered. These include phagocytosis, endocytosis, antibody-dependent cellular cytotoxicity (ADCC), release of inflammatory mediators, and enhancement of antigen presentation. In the last few years our understanding of the Fc gamma receptor structure has increased dramatically, due to the availability of monoclonal antibodies (mAb) and cDNA probes. Fc gamma R are members of the immunoglobulin superfamily and three main classes, hFc gamma RI, hFc gamma RII, and hFc gamma RIII are recognized in man generating at least 12 different isoforms. A further level of complexity is introduced by various genetic polymorphisms and, importantly, recent evidence points at the relevance of this Fc gamma R heterogeneity.
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              Prevention of congenital abnormalities by periconceptional multivitamin supplementation.

              To study the effect of periconceptional multivitamin supplementation on neural tube defects and other congenital abnormality entities. Randomised controlled trial of supplementation with multivitamins and trace elements. Hungarian family planning programme. 4156 pregnancies with known outcome and 3713 infants evaluated in the eighth month of life. A single tablet of a multivitamin including 0.8 mg of folic acid or trace elements supplement daily for at least one month before conception and at least two months after conception. Number of major and mild congenital abnormalities. The rate of all major congenital abnormalities was significantly lower in the group given vitamins than in the group given trace elements and this difference cannot be explained totally by the significant reduction of neural tube defects. The rate of major congenital abnormalities other than neural tube defects and genetic syndromes was 9.0/1000 in pregnancies with known outcome in the vitamin group and 16.6/1000 in the trace element group; relative risk 1.85 (95% confidence interval 1.02 to 3.38); difference, 7.6/1000. The rate of all major congenital abnormalities other than neural tube defects and genetic syndromes diagnosed up to the eighth month of life was 14.7/1000 informative pregnancies in the vitamin group and 28.3/1000 in the trace element group; relative risk 1.95 (1.23 to 3.09); difference, 13.6/1000. The rate of some congenital abnormalities was lower in the vitamin group than in the trace element group but the differences for each group of abnormalities were not significant. Periconceptional multivitamin supplementation can reduce not only the rate of neural tube defects but also the rate of other major non-genetic syndromatic congenital abnormalities. Further studies are needed to differentiate the chance effect and vitamin dependent effect.

                Author and article information

                Journal
                Ir J Med Sci
                Ir J Med Sci
                Irish Journal of Medical Science
                Springer-Verlag (London )
                0021-1265
                1863-4362
                1995
                : 164
                : Suppl 14
                : 1
                Article
                BF02967283
                10.1007/BF02967283
                7103225
                7607850
                e31b7f3e-1024-46e5-8f09-35895f1c4469
                © Springer 1995

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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                © Springer 1995

                Medicine
                acquire immune deficiency syndrome,coeliac disease,methicillin resistant staphylococcus aureus,graft versus host disease,irish journal

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