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      Isoform cell type specificity in the mouse primary motor cortex

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          Abstract

          Full-length SMART-Seq single-cell RNA-seq can be used to measure gene expression at isoform resolution, making possible the identification of isoform markers for cell types and for an isoform atlas. In a comprehensive analysis of 6,160 mouse primary motor cortex cells assayed with SMART-Seq, we find numerous examples of isoform specificity in cell types, including isoform shifts between cell types that are masked in gene-level analysis. These findings can be used to refine spatial gene expression information to isoform resolution. Our results highlight the utility of full-length single-cell RNA-seq when used in conjunction with other single-cell RNA-seq technologies.

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          Author and article information

          Journal
          bioRxiv
          March 05 2020
          Article
          10.1101/2020.03.05.977991
          © 2020

          Molecular medicine, Neurosciences

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