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      The Intangible Magic of Celebrity Marketing

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      PLoS Medicine
      Public Library of Science

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Drug industry insiders share their tips on using celebrities to market drugs and diseases

          Abstract

          Drug industry insiders share their tips on using celebrities to expand markets

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          Most cited references9

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          Coverage by the news media of the benefits and risks of medications.

          The news media are an important source of information about new medical treatments, but there is concern that some coverage may be inaccurate and overly enthusiastic. We studied coverage by U.S. news media of the benefits and risks of three medications that are used to prevent major diseases. The medications were pravastatin, a cholesterol-lowering drug for the prevention of cardiovascular disease; alendronate, a bisphosphonate for the treatment and prevention of osteoporosis; and aspirin, which is used for the prevention of cardiovascular disease. We analyzed a systematic probability sample of 180 newspaper articles (60 for each drug) and 27 television reports that appeared between 1994 and 1998. Of the 207 stories, 83 (40 percent) did not report benefits quantitatively. Of the 124 that did, 103 (83 percent) reported relative benefits only, 3 (2 percent) absolute benefits only, and 18 (15 percent) both absolute and relative benefits. Of the 207 stories, 98 (47 percent) mentioned potential harm to patients, and only 63 (30 percent) mentioned costs. Of the 170 stories citing an expert or a scientific study, 85 (50 percent) cited at least one expert or study with a financial tie to a manufacturer of the drug that had been disclosed in the scientific literature. These ties were disclosed in only 33 (39 percent) of the 85 stories. News-media stories about medications may include inadequate or incomplete information about the benefits, risks, and costs of the drugs as well as the financial ties between study groups or experts and pharmaceutical manufacturers.
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            Registering clinical trials.

            That it is not possible to find information about all initiated clinical trials is of international concern. This is a particular worry because scientists tend to publish their positive findings more often than their negative findings (publication bias). A comprehensive register of initiated clinical trials, with each trial assigned a unique identifier, would inform reviewers, physicians, and others (eg, consumers) about which trials had been started and directly address the problem of publication bias. Patients and their clinicians could also know which trials are open for enrollment, thus speeding medical advances. Individuals who participate in clinical trials typically provide consent in the belief that they are contributing to medical knowledge. But if the knowledge gained is never reported, the trust between patients and investigators and that between patients and research ethics review boards are both damaged. Ethical issues are of particular concern if industry is gaining financially from public involvement in trials, but refusing to reciprocate by making information from industry-sponsored trials generally available. All stakeholders-investigators, research organizations and institutions, journal editors, lawmakers, consumers, and others-must act now, together and in their own domains, to ensure comprehensive registration of clinical trials.
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              Alosetron: a case study in regulatory capture, or a victory for patients' rights?

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                Author and article information

                Journal
                PLoS Med
                pmed
                PLoS Medicine
                Public Library of Science (San Francisco, USA )
                1549-1277
                1549-1676
                November 2004
                30 November 2004
                : 1
                : 2
                : e42
                Author notes

                Ray Moynihan is an investigative reporter in Washington, District of Columbia, United States of America. His book Selling Sickness, coauthored with Alan Cassels, will be published in 2005. E-mail: raymond.moynihan@ 123456verizon.net

                Competing Interests: The author declares that he has no competing interests.

                Article
                10.1371/journal.pmed.0010042
                529428
                15578110
                e33ecdf6-b376-493d-9214-b066bf7d9840
                Copyright: © 2004 Ray Moynihan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
                History
                Categories
                Essay
                Other
                Pharmacology/Drug Discovery
                Clinical Pharmacology
                Epidemiology/Public Health
                Health Policy
                Drugs and Adverse Drug Reactions
                Regulation
                Communication in Health Care
                Health Policy
                Medical Journals

                Medicine
                Medicine

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