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      A putative transglycosylase encoded by SCO4132 influences morphological differentiation and actinorhodin production in Streptomyces coelicolor.

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          Abstract

          Here we report that tgdA, a novel gene encoding a putative transglycosylase, affects both the morphological differentiation and the yield of blue-pigmented compound actinorhodin in Streptomyces coelicolor. The tgdA null mutant displays sparse aerial hyphae and irregular spore chains frequently lacking chromosomal DNA. Elevated actinorhodin production coincides with the overexpression of actII-orf4 in mutant. tgdA expression is temporally and developmentally regulated. The tgdA orthologs in Streptomyces avermilitis and Streptomyces lividans also affect differentiation.

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          Author and article information

          Journal
          Acta Biochim Biophys Sin (Shanghai)
          Acta biochimica et biophysica Sinica
          Oxford University Press (OUP)
          1745-7270
          1672-9145
          Apr 2013
          : 45
          : 4
          Affiliations
          [1 ] Key Laboratory of Synthetic Biology, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
          Article
          gmt012
          10.1093/abbs/gmt012
          23403510
          e34f0001-60cb-4e9d-b8ff-a287a3d18a06
          History

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