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      Communications

      British Journal of Pharmacology

      Wiley-Blackwell

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          The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

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            Some quantitative uses of drug antagonists.

            Various applications of pA(x) measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of pA(x) measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine-atropine, histamine-atropine and acetylcholine-cinchonidine. A new measure, pA(h), is introduced to express the activity of unsurmountable antagonists.
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              A permanent change in brain function resulting from daily electrical stimulation.

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                Author and article information

                Journal
                British Journal of Pharmacology
                Wiley-Blackwell
                00071188
                June 1985
                June 1985
                : 85
                : S1
                : 204P-393P
                Article
                10.1111/j.1476-5381.1985.tb16242.x
                © 1985

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