Sphingosine-1-phosphate activates mouse vagal airway afferent C-fibres via S1PR3 receptors.

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Abstract

Sphingosine-1-phosphate (S1P) strongly activates mouse vagal C-fibres in the airways. Airway-specific nodose and jugular C-fibre neurons express mRNA coding for the S1P receptor S1PR3. S1P activation of nodose C-fibres is inhibited by a S1PR3 antagonist. S1P activation of nodose C-fibres does not occur in S1PR3 knockout mice.

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Journal

Journal ID (iso-abbrev): J Physiol

Title: The Journal of physiology

Publisher: Wiley

ISSN (Electronic): 1469-7793

ISSN (Print): 0022-3751

Publication date (Electronic): April 2019

Volume: 597

Issue: 7

Affiliations

[1 ] Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

[2 ] Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.

[3 ] Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Article

DOI: 10.1113/JP277521

PMC ID: 6441905

PubMed ID: 30793318

SO-VID: e367721b-3a5f-48fe-8ddb-b694f6f2c68c

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