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      Corticosteroid Regulation of IL-1 Receptors in the Mouse Hippocampus: Effects of Glucocorticoid Treatment, Stress, and Adrenalectomy

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          Interleukin-1 (IL-1) and glucocorticoid hormones represent two key mediators involved in the modulation of the neuroimmunoendocrine response to stress. IL-1 is a potent activator of the hypothalamic-pituitary-adrenal (HP A) axis in rodents. In the immune system, glucocorticoids modulate IL-1 production and a number of IL-1 receptors. However, little information is currently available about the modulatory effects that glucocorticoids might exert on IL-1 receptors in the central nervous system. To this purpose, we carried out a series of studies to investigate the effects of various manipulations of the HPA axis on IL-1 binding to the murine hippocampus. Our results show that IL-1 receptor levels in the hippocampus were slightly decreased below control values in dexamethasone (DEX)-treated animals (0.25 or 1 mg/kg i.p. every 12 h) either in subchronic (5 doses) or chronic (8 days) treatments. Corticosterone (CORT) resulted in a small reduction in IL-1 receptors only when injected subchronically at the dose of 5 mg/kg. When it was given at a lower dose (1.25 mg/kg), injected chronically or implanted subcutaneously as CORT pellets for 8 days, no effect was observed. Neither glucocorticoid modified IL-1 binding when administered as a single injection. Saturation studies after subchronic corticosteroid treatment did not reveal modifications in the number and/or affinity of IL-1 receptors in the hippocampus. The regulation of IL-1 receptors by glucocorticoids was also studied following stimulation of IL-1 production by lipopolysaccharide (LPS). LPS administration (30 µg i.p. 24 and 12 h before sacrifice) resulted in a significant reduction in IL-1 binding, but this effect was not modified by DEX treatment. Exposure to stress (sound, cold exposure or foot shock) once a day for 5 days did not modify IL-1-binding levels in the hippocampus. Moreover, hippocampal IL-1 receptor binding was not changed 2 or 7 days after adrenalectomy. The results of the present study suggest that, in contrast to what has been observed in the immune system, IL-1 receptor levels in the murine hippocampus are relatively resistant to modulation by varying levels of circulating glucocorticoids.

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          Author and article information

          S. Karger AG
          08 April 2008
          : 59
          : 2
          : 120-128
          Department of Psychobiology, Cajal Institute, CSIC, Madrid, Spain
          126648 Neuroendocrinology 1994;59:120–128
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 9
          Cytokines and Cytokine Receptors


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