To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT.
We examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST 10th), and the mean difference in ST between the first and last sessions (mean ΔST last).
Multivariate regression analyses showed associations between initial ST and the total chlorpromazine-equivalent dose of antipsychotics (β=0.363, p<0.05). The total fluoxetine-equivalent dose of antidepressants was associated with ΔST 10th (β=0.486, p<0.01) and mean ΔST last (β=0.472, p<0.01).