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      Inter- and intra-observer repeatability of aortic annulus measurements on screening CT for transcatheter aortic valve replacement (TAVR): Implications for appropriate device sizing

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          Abstract

          <div class="section"> <a class="named-anchor" id="S1"> <!-- named anchor --> </a> <h5 class="section-title" id="d6652901e233">Objectives:</h5> <p id="P1">To investigate intra- and inter-observer repeatability of aortic annulus CT measurements for transcatheter aortic valve replacement (TAVR) by readers with different levels of experience and evaluate the impact of different multi-reader paradigms to improve prosthesis sizing. </p> </div><div class="section"> <a class="named-anchor" id="S2"> <!-- named anchor --> </a> <h5 class="section-title" id="d6652901e238">Methods:</h5> <p id="P2">82 TAVR screening CTAs were evaluated twice by three raters with six (R1=radiologist), three (R2=3D-laboratory technician) or zero (R3=medical student) years of experience. Results were translated into hypothetical TAVR size recommendations. Intra- and inter-observer repeatability between single readers and three different multi-reader paradigms ([A]: two readers, [B]: three readers, or [C]: two readers + an optional third reader) were evaluated. </p> </div><div class="section"> <a class="named-anchor" id="S3"> <!-- named anchor --> </a> <h5 class="section-title" id="d6652901e243">Results:</h5> <p id="P3">Intra-observer variability did not differ significantly (range: 50.1-67.8mm <sup>2</sup>). However, we found significant differences in mean inter-observer variance (p=0.001). Multi-reader paradigms led to significantly increased precision (lower variability) for scenarios [B] and [C] (p=0.03, p&lt;0.05). Compared to single readers, all multi-reader strategies clearly lowered the rate of discrepant device size categorization between repeated measurements (22-26% to 5-10%). </p> </div><div class="section"> <a class="named-anchor" id="S4"> <!-- named anchor --> </a> <h5 class="section-title" id="d6652901e251">Conclusions:</h5> <p id="P4">Aortic annulus CT measurements for TAVR are highly reproducible. Multi-reader strategies provide higher precision than evaluations from single readers with different levels of experience and could effectively be implemented with two readers and an optional third reader (Paradigm C) in a clinical setting. </p> </div>

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          Author and article information

          Journal
          European Journal of Radiology
          European Journal of Radiology
          Elsevier BV
          0720048X
          August 2018
          August 2018
          : 105
          : 209-215
          Article
          10.1016/j.ejrad.2018.06.003
          6082406
          30017282
          © 2018

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