A 49-year-old man with a silent remote postero-inferior wall myocardial infarction exhibited recurrent episodes of sustained ventricular tachycardia which was hemodynamically well tolerated. Ventricular tachycardia was neither terminated nor prevented by therapy with multiple class I and class III antiarrhythmic drugs. In contrast, ventricular tachycardia was repeatedly terminated within a few minutes following intravenous administration of 10 mg verapamil and did not recur during oral therapy with verapamil (360 mg daily). Electrophysiologic study suggested that ventricular tachycardia was due to a reentrant mechanism rather than to triggered or abnormal automaticity. Thus, in contrast to previous reports, findings in this patient indicate that verapamil may be very effective and safe in certain types of ventricular tachycardia occurring late after a myocardial infarction.