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      Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area

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      Brain Research

      Elsevier BV

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          Abstract

          In unanesthetized rats the intravenous administration of low doses of ethanol (0.125-0.5 g/kg) produced a dose-dependent increase (30-80%) in the firing rate of dopaminergic (DA) neurons in the Ventral Tegmental Area (VTA). In agreement with previous observations, a dose range between 0.5 and 2 g/mg of ethanol was needed to produce comparable stimulant responses in DA neurons of the Substantia Nigra Pars Compacta. However, in anesthetized rats, doses of ethanol up to 1 g/kg failed to activate VTA-DA neurons. The high sensitivity of VTA-DA neurons to ethanol activation suggests that they might be involved in the reinforcing properties of the drug.

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          Author and article information

          Journal
          Brain Research
          Brain Research
          Elsevier BV
          00068993
          November 1985
          November 1985
          : 348
          : 1
          : 201-203
          Article
          10.1016/0006-8993(85)90381-6
          2998561
          © 1985

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