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MAPK signal pathways in the regulation of cell proliferation in mammalian cells
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Abstract
MAPK families play an important role in complex cellular programs like proliferation,
differentiation, development, transformation, and apoptosis. At least three MAPK families
have been characterized: extracellular signal-regulated kinase (ERK), Jun kinase (JNK/SAPK)
and p38 MAPK. The above effects are fulfilled by regulation of cell cycle engine and
other cell proliferation related proteins. In this paper we discussed their functions
and cooperation with other signal pathways in regulation of cell proliferation.