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      Synaptic Activation of Rat Supraoptic Neurons by Osmotic Stimulation of the Organum vasculosum lamina terminalis

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          Abstract

          Intracellular recordings were obtained from neurons of the supraoptic nucleus in superfused explants of rat hypothalamus in vitro. Transient hyperosmotic stimulation of the organum vasculosum lamina terminalis (OVLT) area caused long-lasting increases in the frequency of excitatory post-synaptic potentials and an associated rise in the rate of action potential discharge. Such responses could be evoked by small (<+2%) increases in osmolality, but not by isotonic solutions. These results suggest that the OVLT plays a functional role in the osmoregulation of neurohypophyseal hormone release.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1992
          1992
          07 April 2008
          : 55
          : 5
          : 609-611
          Affiliations
          Centre for Research in Neuroscience, Montreal General Hospital, Montreal, Canada
          Article
          126174 Neuroendocrinology 1992;55:609–611
          10.1159/000126174
          1584342
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 3
          Categories
          Short Communication

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