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      Malignant Hypertension with a Rare Complication of Pulmonary Alveolar Hemorrhage

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          Abstract

          A 34-year-old Japanese male was admitted to Okayama University Hospital with severe hypertension, rapidly progressive renal failure, blurred vision, dyspnea and hemoptysis. Clinical diagnosis of malignant hypertension was given and antihypertensive therapy and hemodialysis were immediately started. Renal biopsy was performed on the sixth day in hospital to examine the underlying disease, such as microscopic form of polyarteritis, since the complaint of hemoptysis and pulmonary alveolar hemorrhage was noted by computed tomography of the lungs. Typical pathological changes of malignant hypertension, i.e. fibrinoid necrosis of the afferent arterioles and proliferative endoarteritis at the interlobular arteries were observed. There was no evidence of active necrotizing glomerulonephritis and crescent formation. Renal function was gradually recovered and pulmonary hemorrhage completely disappeared by treatment with antihypertensive agents. The authors report a case of malignant hypertension with a rare complication of pulmonary alveolar hemorrhage and speculate that it may be related to vascular injuries at the alveolar capillary level caused by malignant hypertension.

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          Author and article information

          Journal
          AJN
          Am J Nephrol
          10.1159/issn.0250-8095
          American Journal of Nephrology
          S. Karger AG
          0250-8095
          1421-9670
          2000
          February 2000
          13 January 2000
          : 20
          : 1
          : 64-67
          Affiliations
          aDepartment of Medicine III, Okayama University Medical School, Okayama, bDepartment of Internal Medicine, Kawasaki Medical Hospital, Kawasaki, Japan
          Article
          13558 Am J Nephrol 2000;20:64–67
          10.1159/000013558
          10644871
          © 2000 S. Karger AG, Basel

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          Page count
          Figures: 2, References: 8, Pages: 4
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/13558
          Categories
          Case Report

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