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      Renal Functional and Organic Changes Induced by Salt and Prostaglandin Inhibition in Spontaneously Hypertensive Rats

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      S. Karger AG

      Meclofenamate, Prostaglandins, Rats, Renal, Hemodynamics, Hypertension

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          The prolonged (3 months) effects of high sodium intake and sodium meclofenamate were studied in two groups of male spontaneously hypertensive rats. Group 1 (8 rats) received 1% NaCl in tap water ad libitum and served as control. Group 2 (8 rats) received, besides 1 % NaCl in tap water, 50 µg/ml of sodium meclofenamate per rat daily. Renal metabolic, hemodynamic and histologic studies were done at the end of the study. The renal functional studies were performed in the unanesthetized, unrestrained state. Group 2 rats developed significantly higher arterial pressures, renal vascular resistance and histologic changes (p < 0.005), larger left ventricular weights (p < 0.05) and significantly lower effective renal plasma flow, renal blood flow (p < 0.005) and glomerular filtration rate (p < 0.05) than group 1 rats. There were no differences between the two groups of rats with respect to heart rate, hematocrit, right ventricular weight, body weight, fluid intake, urine output, sodium and potassium excretion and serum electrolytes. The results suggest that the combination of high sodium intake and prostaglandin synthesis inhibition exert a greater damaging effect on the arterial pressure and renal function of spontaneously hypertensive rats than salt alone.

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          Author and article information

          S. Karger AG
          02 December 2008
          : 25
          : 3
          : 151-155
          Department of Medicine, University of Oklahoma Health Sciences Center, and Veterans Administration Hospital, Oklahoma City, Okla.
          181772 Nephron 1980;25:151–155
          © 1980 S. Karger AG, Basel

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          Page count
          Pages: 5
          Original Paper

          Cardiovascular Medicine, Nephrology

          Rats, Prostaglandins, Meclofenamate, Renal, Hemodynamics, Hypertension


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