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      Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents.

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          Abstract

          High concentrations of interferon beta (IFN-beta) inhibit malignant cell growth in vitro. However, the therapeutic utility of IFN-beta in vivo is limited by its excessive toxicity when administered systemically at high doses. Mesenchymal stem cells (MSC) can be used to target delivery of agents to tumor cells. We tested whether MSC can deliver IFN-beta to tumors, reducing toxicity.

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          Author and article information

          Journal
          J Natl Cancer Inst
          Journal of the National Cancer Institute
          Oxford University Press (OUP)
          1460-2105
          0027-8874
          Nov 03 2004
          : 96
          : 21
          Affiliations
          [1 ] Department of Blood and Marrow Transplantation, Section of Molecular Hematology and Therapy, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 448, Houston, TX 77030, USA.
          Article
          96/21/1593
          10.1093/jnci/djh299
          15523088
          e3aa5c63-bcdf-433e-9174-d5512ca84093
          History

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