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      Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders.

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      Current molecular medicine

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          Abstract

          Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with complex genetic architectures but overlapping behavioral phenotypes, which suggests common pathway perturbations. Multiple lines of evidence implicate imbalances in excitatory and inhibitory activity (E/I imbalance) as a shared pathophysiological mechanism. Thus, understanding the molecular underpinnings of E/I imbalance may provide essential insight into the etiology of these disorders and may uncover novel targets for future drug discovery. Here, we review key genetic, physiological, neuropathological, functional, and pathway studies that suggest alterations to excitatory/inhibitory circuits are keys to ASD and SCZ pathogenesis.

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          Author and article information

          Journal
          Curr. Mol. Med.
          Current molecular medicine
          1875-5666
          1566-5240
          2015
          : 15
          : 2
          Affiliations
          [1 ] Department of Physiology, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA. p-penzes@northwestern.edu.
          Article
          CMM-EPUB-65609 NIHMS749865
          10.2174/1566524015666150303003028
          4721588
          25732149
          e3dab0b6-052b-4590-946f-a5107daa7014
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