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      (R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents.

      Bioorganic & Medicinal Chemistry Letters
      Animals, Benzofurans, chemical synthesis, chemistry, pharmacology, Cloning, Molecular, Humans, Ligands, Melatonin, agonists, Mice, Molecular Structure, NIH 3T3 Cells, Protein Binding, drug effects, Rats, Receptor, Melatonin, MT1, metabolism, Receptor, Melatonin, MT2, Recombinant Proteins, Structure-Activity Relationship, Vasoconstriction, Vasoconstrictor Agents

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          Abstract

          (R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives (e.g., 3 and 4) were synthesized as novel melatoninergic ligands with significantly lower vasoconstrictive activity in vitro in the rat tail artery. Binding affinity assays were performed on cloned human MT1 and MT2 receptors stably expressed in NIH3T3 cells.

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