Record: found
Abstract: found
Article: not found

Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement.

Author(s): Johann Leban, Wael Saeb, Roland Baumgartner, Bernd Kramer, Gabriel García-Soto

Publication date: 2004-01-05

Journal: Bioorganic & Medicinal Chemistry Letters

Keywords: Binding Sites, drug effects, physiology, Enzyme Inhibitors, chemistry, metabolism, pharmacology, Humans, Oxidoreductases Acting on CH-CH Group Donors, antagonists & inhibitors, Quantitative Structure-Activity Relationship

Read this article at

ScienceOpenPublisher PubMed

Bookmark

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

A novel series of DHODH inhibitors was developed based on a lead which was obtained by a docking procedure and a medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method to yield low nanomolar inhibitors.

Related collections

Author and article information

Journal

PubMed ID:: 14684297

DOI:: 10.1016/j.bmcl.2003.10.021

ScienceOpen disciplines: Chemistry

Keywords: Binding Sites,drug effects,physiology,Enzyme Inhibitors,chemistry,metabolism,pharmacology,Humans,Oxidoreductases Acting on CH-CH Group Donors,antagonists & inhibitors,Quantitative Structure-Activity Relationship

Data availability:

ScienceOpen disciplines: Chemistry

Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement.

Read this article at

Abstract

Related collections

Drug_transporters

Author and article information

Journal

Comments

Comment on this article

Similar content 180

Cited by 7