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Synthesis and evaluation of pH dependent hydrogels for controlled release of venlafaxine HCl

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      pH dependent hydrogel formulations of venlafexine HCl were prepared by free radical polymerization method using polyethylene glycol as polymer. Various samples were prepared with varying concentration of polymer, monomer and cross-linker to study their effect on gel swelling, diffusion characteristics and drug release. Swelling was found to be increased with increase in pH. Increase in acrylic acid concentration increases swelling while increase in cross-linker concentration has an opposite effect on swelling. Drug release study was performed in pH 1.2, 5.5 and 7.5 for 12 hours at 37 °C and drug release was found to increase in higher pH. Prepared hydrogel preparations were also characterized by PXRD, TGA, SEM and FTIR.

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      Hydrogel: Preparation, characterization, and applications: A review

       Enas M Ahmed (2013)
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        Affiliations
        [a ]University College of Pharmacy, University of the Punjab, Lahore, Pakistan
        [b ]Akson College of Pharmacy, Mirpur, AJ &K, Pakistan
        Author notes
        *Corresponding author. Tel.: +92 42 99211616 Fax: +92 42 99211616 E-mail: nadeem_irfan@ 123456hotmail.com nasirabbas77@ 123456gmail.com
        Journal
        BJPharm
        British Journal of Pharmacy
        University of Huddersfield Press
        2058-8356
        11 July 2018
        : 2
        : 2 , Proceedings of the 8 th APS International PharmSci 2017
        : S43-S44
        10.5920/bjpharm.2017.30
        © 2017, Nasir Abbas, Qazi Amir Ijaz, Amjad Hussain, Nadeem Irfan Bukhari

        This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0 https://creativecommons.org/licenses/by/4.0/.

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