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      Nitroprusside-Sparing Effects of Enoximone

      ,

      Cardiology

      S. Karger AG

      Closed-loop control, Hypertension, Cardiac surgery, Enoximone

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          Abstract

          Thirty patients who had undergone coronary artery bypass grafting and who required vasodilator therapy for control of arterial hypertension were allocated to receive either low-dose or high-dose enoximone or placebo infusions. A closed-loop arterial pressure control system was used to assess cardiovascular stability and the amount of sodium nitro-prusside required to maintain control. There were no significant differences between the three groups in the time spent at 10, 20 and 30 mm Hg below the target pressure or at 10 and 20 mm Hg above the target pressure. However, the low-dose enoximone group spent a statistically greater amount of time at 30 mm Hg above the target pressure. There were no significant differences in the amount of sodium nitroprusside required to maintain control, in the duration of sodium nitroprusside infusion or in the heart rate. In conclusion, enoximone was not associated with a clinically significant effect on systolic pressure.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-5255-4
          978-3-318-00032-0
          0008-6312
          1421-9751
          1990
          1990
          12 November 2008
          : 77
          : Suppl 3
          : 46-50
          Affiliations
          University Department of Anaesthesia, Glasgow Royal Infirmary, Glasgow, UK
          Article
          174671 Cardiology 1990;77:46–50
          10.1159/000174671
          2148280
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
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