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      Relationship between prostate volume changes and treatment duration of neoadjuvant androgen deprivation during intensity-modulated radiation therapy for Japanese patients with prostate cancer

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          ABSTRACT

          The application of neoadjuvant androgen deprivation (NAD) in prostate cancer leads to a reduction in prostate volume, and the trends in volume reduction differ according to the treatment duration of NAD. A reduction in volume during external beam radiation therapy may lead to the exposure of normal tissues to an unexpected dose. In fact, prostate volume reductions have primarily been reported in European and American institutions. Although the prostate volume of Japanese patients is known to be small, the trends in prostate volume change during radiation therapy remain unclear. In the present study, we aimed to evaluate the changes in prostate volume of Japanese patients during intensity-modulated radiation therapy (IMRT) with NAD. Nineteen Japanese patients with prostate cancer underwent IMRT with NAD. Kilovoltage computed tomography (CT) images were obtained for treatment planning and verification of the treatment position for each treatment fraction. The patients were divided into 3 groups based on the duration of NAD, as follows: NAD < 3 months (short NAD: S-NAD), 3 months ≤ NAD < 6 months (middle NAD: M-NAD), and NAD ≥ 6 months (long NAD: L-NAD). The prostate volume reductions at the 36th treatment fraction, relative to the planning CT, were 7.8%, 2.0%, and 1.7% for the S-NAD, M-NAD, and L-NAD groups, respectively. Prostate volume shrunk greater in the S-NAD group than in the M-NAD and L-NAD groups; this finding was consistent with those of previous studies. The prostate volume changes in Japanese patients were smaller compared to those in European and American patients.

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          Author and article information

          Journal
          Nagoya J Med Sci
          Nagoya J Med Sci
          Nagoya Journal of Medical Science
          Nagoya University
          0027-7622
          2186-3326
          August 2016
          : 78
          : 3
          : 313-321
          Affiliations
          [1 ]Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
          [2 ]Radiological Technology, Department of Medical Technique, Nagoya University Hospital, Nagoya, Japan
          [3 ]Department of Therapeutic Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
          Author notes

          Corresponding author: Takeshi Kamomae, PhD

          Department of Therapeutic Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan

          TEL: +81-52-744-2327, FAX: +81-52-744-2335, E-mail: kamomae@med.nagoya-u.ac.jp

          Article
          4995277
          e410ebc5-b3c3-407c-9115-6ed5cd9b9add

          This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit ( http://creativecommons.org/licenses/by-nc-nd/4.0/).

          History
          : 2 February 2016
          : 12 July 2016
          Categories
          Original Paper

          prostate cancer,neoadjuvant androgen deprivation,imrt,igrt,japanese patients

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