17
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      LIPE C-60G influences the effects of physical activity on body fat and plasma lipid concentrations: the Quebec Family Study

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A large body of evidence suggests that the environment plays an important role in the development of obesity. The hormone-sensitive lipase (encoded by the LIPE gene) is an intracellular enzyme that mobilises fat stores in a hormone-stimulated manner. The aim of the present study was to determine the effects of the LIPE C-60G polymorphism on body fat and plasma lipid and lipoprotein concentrations, and to test for its interaction with physical activity. The LIPE C-60G polymorphism was genotyped in 862 subjects from the Quebec Family Study. Body mass index (BMI), fat mass, percentage body fat, abdominal fat areas assessed by computed tomography, and detailed fasting plasma lipid and lipoprotein profiles were measured. Levels of physical activity were estimated using a three-day diary, and a moderate to strenuous physical activity score was retained for this study. The main effects of the LIPE C-60G polymorphism, physical activity and their interaction were determined by regression analyses separately in men and women using the MIXED model procedure. In men, we observed significant gene-physical activity interactions for BMI ( p = 0.006), fat mass ( p = 0.04), abdominal visceral fat area ( p = 0.005) and plasma cholesterol (C) high-density lipoprotein cholesterol (HDL-C) ratio ( p = 0.003). A high level of physical activity was associated with reduced adiposity and a lower plasma-C/HDL-C ratio, but only in non-carriers of the genetic variant (G-60 allele). In women, no evidence of a gene by physical activity interaction was observed, except for subcutaneous abdominal fat ( p = 0.05). These results suggest that the associations between physical activity and body fat and plasma lipoprotein/lipid concentrations in men are dependent on the LIPE C-60G polymorphism, and highlight the importance of taking into account the role of gene-physical activity interactions in candidate gene studies of obesity and obesity-related traits.

          Related collections

          Most cited references29

          • Record: found
          • Abstract: found
          • Article: not found

          A method to assess energy expenditure in children and adults.

          A variety of studies has a need to estimate the amount and pattern of daily energy expenditure. To this end, a 3-day activity record was developed and is described. Every 15-min period over 3 days, including a weekend day, was qualified in terms of energy cost on a 1 to 9 scale corresponding to a range of 1.0 MET to 7.8 METs and higher. A reliability study of 61 subjects indicated a highly reproducible procedure as shown by an intraclass correlation of 0.96 for mean kcal of energy expenditure over 3 days. Repeatability was unchanged whether or not the hours of sleep were included in the record. Samples of 150 children and 150 adults were also drawn to investigate the relationship between energy expenditure, physical working capacity, and body fatness. Results support the hypothesis that mean energy expenditure per kg of body weight is significantly correlated with physical working capacity expressed per kg of body weight (r = 0.31; p less than 0.01). Mean energy expenditure per kg of body weight is negatively related to body fat (-0.08 less than or equal to r less than or equal to -0.13). It is concluded that the 3-day activity record is a procedure suitable to estimate energy expenditure in population studies.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            The gross composition of the body.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Molecular mechanisms regulating hormone-sensitive lipase and lipolysis.

              Hormone-sensitive lipase, the rate-limiting enzyme of intracellular TG hydrolysis, is a major determinant of fatty acid mobilization in adipose tissue as well as other tissues. It plays a pivotal role in lipid metabolism, overall energy homeostasis, and, presumably, cellular events involving fatty acid signaling. Detailed knowledge about its structure and regulation may provide information regarding the pathogenesis of such human diseases as obesity and diabetes and may generate concepts for new treatments of these diseases. The current review summarizes the recent advances with regard to hormone-sensitive lipase structure and molecular mechanisms involved in regulating its activity and lipolysis in general. A summary of the current knowledge regarding regulation of expression, potential involvement in lipid disorders, and role in tissues other than adipose tissue is also provided.
                Bookmark

                Author and article information

                Journal
                Hum Genomics
                Hum. Genomics
                Human Genomics
                BioMed Central
                1473-9542
                1479-7364
                2009
                1 January 2009
                : 3
                : 2
                : 157-168
                Affiliations
                [1 ]Département de Médecine, Université Laval, Québec, QC, G1K 7P4 Canada
                [2 ]Centre de recherche sur les maladies lipidiques (CRML), Centre de Recherche du Centre Hospitalier de l'Université Laval du CHUQ, Université Laval, Québec, QC, G1V 4G2 Canada
                [3 ]Département des sciences des Aliments etde Nutrition, Université Laval, Québec, QC, G1K 7P4 Canada
                [4 ]Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808 USA
                [5 ]Division de Kinésiologie, Département de médecine sociale et préventive, Université Laval, Québec, QC, G1K 7P4 Canada
                Article
                1479-7364-3-2-157
                10.1186/1479-7364-3-2-157
                3525276
                19164092
                e41b6a81-4708-4727-a006-588cf73f36f6
                Copyright ©2009 Henry Stewart Publications
                History
                : 9 July 2008
                : 9 July 2008
                Categories
                Primary Research

                Genetics
                hormone-sensitive lipase,plasma lipid and lipoprotein levels,body fat,gene-environment interaction

                Comments

                Comment on this article