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      The contributions of the Genome Project to the study of schistosomiasis

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          Abstract

          In this paper we review the impact that the availability of the Schistosoma mansoni genome sequence and annotation has had on schistosomiasis research. Easy access to the genomic information is important and several types of data are currently being integrated, such as proteomics, microarray and polymorphic loci. Access to the genome annotation and powerful means of extracting information are major resources to the research community.

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          The Gene Ontology (GO) database and informatics resource.

          Gene Ontology Consortium (2004)
          The Gene Ontology (GO) project (http://www. geneontology.org/) provides structured, controlled vocabularies and classifications that cover several domains of molecular and cellular biology and are freely available for community use in the annotation of genes, gene products and sequences. Many model organism databases and genome annotation groups use the GO and contribute their annotation sets to the GO resource. The GO database integrates the vocabularies and contributed annotations and provides full access to this information in several formats. Members of the GO Consortium continually work collectively, involving outside experts as needed, to expand and update the GO vocabularies. The GO Web resource also provides access to extensive documentation about the GO project and links to applications that use GO data for functional analyses.
          Article 0 comments Cited 493 times – based on 0 reviews     Review now
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            ToxoDB: an integrated Toxoplasma gondii database resource

            Bindu Gajria, Amit Bahl, John Brestelli … (2008)
            ToxoDB (http://ToxoDB.org) is a genome and functional genomic database for the protozoan parasite Toxoplasma gondii. It incorporates the sequence and annotation of the T. gondii ME49 strain, as well as genome sequences for the GT1, VEG and RH (Chr Ia, Chr Ib) strains. Sequence information is integrated with various other genomic-scale data, including community annotation, ESTs, gene expression and proteomics data. ToxoDB has matured significantly since its initial release. Here we outline the numerous updates with respect to the data and increased functionality available on the website.
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              PlasmoDB: a functional genomic database for malaria parasites

              Cristina Aurrecoechea, John Brestelli, Brian Brunk … (2009)
              PlasmoDB (http://PlasmoDB.org) is a functional genomic database for Plasmodium spp. that provides a resource for data analysis and visualization in a gene-by-gene or genome-wide scale. PlasmoDB belongs to a family of genomic resources that are housed under the EuPathDB (http://EuPathDB.org) Bioinformatics Resource Center (BRC) umbrella. The latest release, PlasmoDB 5.5, contains numerous new data types from several broad categories—annotated genomes, evidence of transcription, proteomics evidence, protein function evidence, population biology and evolution. Data in PlasmoDB can be queried by selecting the data of interest from a query grid or drop down menus. Various results can then be combined with each other on the query history page. Search results can be downloaded with associated functional data and registered users can store their query history for future retrieval or analysis.
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                Author and article information

                Journal
                Journal ID (publisher-id): mioc
                Title: Memórias do Instituto Oswaldo Cruz
                Abbreviated Title: Mem. Inst. Oswaldo Cruz
                Publisher: Instituto Oswaldo Cruz, Ministério da Saúde (Rio de Janeiro, RJ, Brazil )
                ISSN (Print): 0074-0276
                ISSN (Electronic): 1678-8060
                Publication date (Print and electronic): July 2010
                Volume: 105
                Issue: 4
                Pages: 367-369
                Affiliations
                [01] Belo Horizonte MG orgnameInstituto de Pesquisa René Rachou-Fiocruz orgdiv1Laboratório de Parasitologia Celular e Molecular orgdiv2Centro de Excelência em Bioinformática Brasil
                Article
                Publisher ID: S0074-02762010000400003 Publisher ID: S0074-0276(10)10500400003
                DOI: 10.1590/S0074-02762010000400003
                SO-VID: e42f09a3-97e7-4d39-a641-ce2472107823
                License:

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                Date accepted : 04 September 2009
                Date received : 08 January 2009
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 21, Pages: 3
                Product

                SciELO Brazil

                Categories
                Subject: Articles

                Keywords: Schistosoma mansoni,genome,database,data integration
                Data availability:
                Keywords: Schistosoma mansoni, genome, database, data integration

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