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      Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.

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          Abstract

          Integrin-mediated cell adhesions provide dynamic, bidirectional links between the extracellular matrix and the cytoskeleton. Besides having central roles in cell migration and morphogenesis, focal adhesions and related structures convey information across the cell membrane, to regulate extracellular-matrix assembly, cell proliferation, differentiation, and death. This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0072
          1471-0072
          Nov 2001
          : 2
          : 11
          Affiliations
          [1 ] Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel. benny.geiger@weizmann.ac.il
          Article
          35099066
          10.1038/35099066
          11715046
          e441f7b3-6700-4366-b88c-7da303776f90
          History

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