Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial.

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Abstract

Evidence is weak for the ability of long-term non-invasive positive pressure ventilation (NPPV) to improve survival in patients with stable hypercapnic chronic obstructive pulmonary disease (COPD). Previous prospective studies did not target a reduction in hypercapnia when adjusting ventilator settings. This study investigated the effect of long-term NPPV, targeted to markedly reduce hypercapnia, on survival in patients with advanced, stable hypercapnic COPD.

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Journal

Journal ID (iso-abbrev): Lancet Respir Med

Title: The Lancet. Respiratory medicine

ISSN (Electronic): 2213-2619

ISSN (Print): 2213-2600

Publication date (Electronic): Sep 2014

Volume: 2

Issue: 9

Affiliations

[1 ] From the Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany. Electronic address: koehnlein.thomas@mh-hannover.de.

[2 ] Centre for Respiratory Medicine, Hospital Köln-Merheim, University of Witten/Herdecke, Cologne, Germany.

[3 ] Department of Pneumology I, Fachkrankenhaus Kloster Grafschaft, Schmallenberg, Germany.

[4 ] Department of Medical Biometry and Epidemiology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

[5 ] Centre of Pneumology and Thoracic Surgery, Asklepios Hospital Gauting, Department of Intensive Care Medicine and Long-term Ventilation, Gauting, Germany.

[6 ] Department of Respiratory and Critical Care Medicine, and Ludwig Boltzmann Institute of COPD and Respiratory Epidemiology, Otto Wagner Hospital, Vienna, Austria.

[7 ] Department of Respiratory Medicine, Evangelisches Klinikum Niederrhein, Oberhausen, Germany.

[8 ] Department of Specialist, Diagnostic, and Experimental Medicine, School of Medicine, Università di Bologna, Bologna, Italy.

[9 ] Department of Respiratory Medicine, Klinikum Oststadt-Heidehaus, Hannover, Germany.

[10 ] LungenClinic Grosshansdorf, Center for Pneumology and Thoracic Surgery, Grosshansdorf, Germany.

[11 ] Department of Pneumology, Respiratory Care, and Sleep Medicine, Evangelisches Krankenhaus Göttingen-Weende, Bovenden-Lenglern, Germany.

[12 ] Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany; Member of the German Centre for Lung Research.

Article

Publisher Item ID: S2213-2600(14)70153-5

DOI: 10.1016/S2213-2600(14)70153-5

PubMed ID: 25066329

SO-VID: e4490156-06c8-4cd1-9993-36792f840022

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