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      Impacts and interactions of COVID-19 response involvement, health-related behaviours, health literacy on anxiety, depression and health-related quality of life among healthcare workers: a cross-sectional study

      research-article
      1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 1 , 29 , 3 , 30 , 31 , 32 , 31 , 33 , 34 , 35 , 36 , 35 , 37 , 35 ,
      BMJ Open
      BMJ Publishing Group
      epidemiology, public health, infection control, occupational & industrial medicine, anxiety disorders, depression & mood disorders

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          Abstract

          Objectives

          We examined impacts and interactions of COVID-19 response involvement, health-related behaviours and health literacy (HL) on anxiety, depression, and health-related quality of life (HRQoL) among healthcare workers (HCWs).

          Design

          A cross-sectional study was conducted. Data were collected 6 April to 19 April 2020 using online-based, self-administered questionnaires.

          Setting

          19 hospitals and health centres in Vietnam.

          Participants

          7 124 HCWs aged 21–60 years.

          Results

          The COVID-19 response-involved HCWs had higher anxiety likelihood (OR (95% CI)=4.41 (3.53 to 5.51)), higher depression likelihood (OR(95% CI)=3.31 (2.71 to 4.05)) and lower HRQoL score (coefficient, b(95% CI)=−2.14 (−2.89 to −1.38)), compared with uninvolved HCWs. Overall, HCWs who smoked or drank at unchanged/increased levels had higher likelihood of anxiety, depression and lower HRQoL scores; those with unchanged/healthier eating, unchanged/more physical activity and higher HL scores had lower likelihood of anxiety, depression and higher HRQoL scores. In comparison to uninvolved HCWs who smoked or drank at never/stopped/reduced levels, involved HCWs with unchanged/increased smoking or drinking had lower anxiety likelihood (OR(95% CI)=0.34 (0.14 to 0.83)) or (OR(95% CI)=0.26 (0.11 to 0.60)), and lower depression likelihood (OR(95% CI)=0.33 (0.15 to 0.74)) or (OR(95% CI)=0.24 (0.11 to 0.53)), respectively. In comparison with uninvolved HCWs who exercised at never/stopped/reduced levels, or with those in the lowest HL quartile, involved HCWs with unchanged/increased exercise or with one-quartile HL increment reported lower anxiety likelihood (OR(95% CI)=0.50 (0.31 to 0.81)) or (OR(95% CI)=0.57 (0.45 to 0.71)), lower depression likelihood (OR(95% CI)=0.40 (0.27 to 0.61)) or (OR(95% CI)=0.63 (0.52 to 0.76)), and higher HRQoL scores (b(95% CI)=2.08 (0.58 to 3.58)), or (b(95% CI)=1.10 (0.42 to 1.78)), respectively.

          Conclusions

          Physical activity and higher HL were found to protect against anxiety and depression and were associated with higher HRQoL. Unexpectedly, smoking and drinking were also found to be coping behaviours. It is important to have strategic approaches that protect HCWs’ mental health and HRQoL.

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          Most cited references98

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          • Article: not found

          A brief measure for assessing generalized anxiety disorder: the GAD-7.

          Generalized anxiety disorder (GAD) is one of the most common mental disorders; however, there is no brief clinical measure for assessing GAD. The objective of this study was to develop a brief self-report scale to identify probable cases of GAD and evaluate its reliability and validity. A criterion-standard study was performed in 15 primary care clinics in the United States from November 2004 through June 2005. Of a total of 2740 adult patients completing a study questionnaire, 965 patients had a telephone interview with a mental health professional within 1 week. For criterion and construct validity, GAD self-report scale diagnoses were compared with independent diagnoses made by mental health professionals; functional status measures; disability days; and health care use. A 7-item anxiety scale (GAD-7) had good reliability, as well as criterion, construct, factorial, and procedural validity. A cut point was identified that optimized sensitivity (89%) and specificity (82%). Increasing scores on the scale were strongly associated with multiple domains of functional impairment (all 6 Medical Outcomes Study Short-Form General Health Survey scales and disability days). Although GAD and depression symptoms frequently co-occurred, factor analysis confirmed them as distinct dimensions. Moreover, GAD and depression symptoms had differing but independent effects on functional impairment and disability. There was good agreement between self-report and interviewer-administered versions of the scale. The GAD-7 is a valid and efficient tool for screening for GAD and assessing its severity in clinical practice and research.
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            The PHQ-9: validity of a brief depression severity measure.

            While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity. The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-9 is the depression module, which scores each of the 9 DSM-IV criteria as "0" (not at all) to "3" (nearly every day). The PHQ-9 was completed by 6,000 patients in 8 primary care clinics and 7 obstetrics-gynecology clinics. Construct validity was assessed using the 20-item Short-Form General Health Survey, self-reported sick days and clinic visits, and symptom-related difficulty. Criterion validity was assessed against an independent structured mental health professional (MHP) interview in a sample of 580 patients. As PHQ-9 depression severity increased, there was a substantial decrease in functional status on all 6 SF-20 subscales. Also, symptom-related difficulty, sick days, and health care utilization increased. Using the MHP reinterview as the criterion standard, a PHQ-9 score > or =10 had a sensitivity of 88% and a specificity of 88% for major depression. PHQ-9 scores of 5, 10, 15, and 20 represented mild, moderate, moderately severe, and severe depression, respectively. Results were similar in the primary care and obstetrics-gynecology samples. In addition to making criteria-based diagnoses of depressive disorders, the PHQ-9 is also a reliable and valid measure of depression severity. These characteristics plus its brevity make the PHQ-9 a useful clinical and research tool.
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              A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation

              The objective of this study was to develop a prospectively applicable method for classifying comorbid conditions which might alter the risk of mortality for use in longitudinal studies. A weighted index that takes into account the number and the seriousness of comorbid disease was developed in a cohort of 559 medical patients. The 1-yr mortality rates for the different scores were: "0", 12% (181); "1-2", 26% (225); "3-4", 52% (71); and "greater than or equal to 5", 85% (82). The index was tested for its ability to predict risk of death from comorbid disease in the second cohort of 685 patients during a 10-yr follow-up. The percent of patients who died of comorbid disease for the different scores were: "0", 8% (588); "1", 25% (54); "2", 48% (25); "greater than or equal to 3", 59% (18). With each increased level of the comorbidity index, there were stepwise increases in the cumulative mortality attributable to comorbid disease (log rank chi 2 = 165; p less than 0.0001). In this longer follow-up, age was also a predictor of mortality (p less than 0.001). The new index performed similarly to a previous system devised by Kaplan and Feinstein. The method of classifying comorbidity provides a simple, readily applicable and valid method of estimating risk of death from comorbid disease for use in longitudinal studies. Further work in larger populations is still required to refine the approach because the number of patients with any given condition in this study was relatively small.
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                Author and article information

                Journal
                BMJ Open
                BMJ Open
                bmjopen
                bmjopen
                BMJ Open
                BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )
                2044-6055
                2020
                7 December 2020
                : 10
                : 12
                : e041394
                Affiliations
                [1 ]departmentDepartment of Infectious Diseases , Vietnam Military Medical University , Ha Noi, Viet Nam
                [2 ]departmentDirector Office , Military Hospital 103 , Hanoi, Hanoi, Viet Nam
                [3 ]departmentDirector Office , Thai Nguyen National Hospital , Thai Nguyen, Viet Nam
                [4 ]departmentPresident Office , Thai Nguyen University of Medicine and Pharmacy , Thai Nguyen, Viet Nam
                [5 ]departmentDepartment of Pulmonary & Cardiovascular Diseases , Hai Phong University of Medicine and Pharmacy Hospital , Haiphong, Viet Nam
                [6 ]departmentDirector Office , Hai Phong University of Medicine and Pharmacy Hospital , Haiphong, Viet Nam
                [7 ]departmentInternational Ph.D. Program in Medicine , Taipei Medical University , Taipei, Taiwan
                [8 ]departmentDirector Office , E Hospital , Hanoi, Hanoi, Viet Nam
                [9 ]departmentDepartment of Thoracic and Cardiovascular Surgery , E Hospital , Hanoi, Viet Nam
                [10 ]departmentDirector Office , General Hospital of Agricultural , Hanoi, Viet Nam
                [11 ]departmentNursing Office , Thien An Obstetrics and Gynecology Hospital , Hanoi, Viet Nam
                [12 ]departmentFaculty of Nursing , Hanoi University of Business and Technology , Hanoi, Viet Nam
                [13 ]departmentDirector Office , Bac Ninh Obstetrics and Pediatrics Hospital , Bac Ninh, UK
                [14 ]departmentDirector Office , Kien An Hospital , Haiphong, Viet Nam
                [15 ]departmentDirector Office , Quang Ninh General Hospital , Quang Ninh, Viet Nam
                [16 ]departmentDirector Office , Bai Chay Hospital , Quang Ninh, Viet Nam
                [17 ]departmentDirector Office , Quang Ninh Obstetrics and Pediatrics Hospital , Quang Ninh, Viet Nam
                [18 ]departmentHealth Management Training Institute , University of Medicine and Pharmacy, Hue University , Thua Thien Hue, Viet Nam
                [19 ]departmentDepartment of Health Economics , Corvinus University of Budapest , Budapest, Hungary
                [20 ]departmentGeneral Planning Department , Danang Oncology Hospital , Danang, Viet Nam
                [21 ]departmentDirector Office , Thu Duc District Health Center , Ho Chi Minh, Viet Nam
                [22 ]departmentFaculty of Health , Mekong University , Vinh Long, Viet Nam
                [23 ]departmentDirector Office , Hospital District 2 , Ho Chi Minh, Viet Nam
                [24 ]departmentNursing Office , Tan Phu District Hospital , Ho Chi Minh, Viet Nam
                [25 ]departmentDirector Office , District 9 Health Center , Ho Chi Minh, Viet Nam
                [26 ]departmentPresident Office , Can Tho University of Medicine and Pharmacy , Can Tho, Viet Nam
                [27 ]departmentAesthetic Plastic Surgery & Skin Care Center , Can Tho University of Medicine and Pharmacy Hospital , Can Tho, Viet Nam
                [28 ]departmentDirector Office , Trieu Phong District Health Center , Quang Tri, Viet Nam
                [29 ]departmentDivision of Military Science , Military Hospital 103 , Hanoi, Hanoi, Viet Nam
                [30 ]departmentDepartment of Internal Medicine , Thai Nguyen University of Medicine and Pharmacy , Thai Nguyen, Viet Nam
                [31 ]departmentFaculty of Public Health , Hai Phong University of Medicine and Pharmacy , Haiphong, Viet Nam
                [32 ]departmentPresident Office , Hai Phong University of Medicine and Pharmacy , Haiphong, Viet Nam
                [33 ]departmentSchool of Public Health , Taipei Medical University , Taipei, Taiwan
                [34 ]departmentDepartment of Health Education, Faculty of Social Sciences, Behavior and Health Education , Hanoi University of Public Health , Hanoi, Viet Nam
                [35 ]departmentSchool of Nutrition and Health Sciences , Taipei Medical University , Taipei, Taiwan
                [36 ]departmentResearch Center of Geriatric Nutrition , Taipei Medical University , Taipei, Taiwan
                [37 ]departmentNutrition Research Center , Taipei Medical University Hospital , Taipei, Taiwan
                Author notes
                [Correspondence to ] Dr Tuyen Van Duong; duongtuyenvna@ 123456gmail.com
                Author information
                http://orcid.org/0000-0002-2287-0723
                Article
                bmjopen-2020-041394
                10.1136/bmjopen-2020-041394
                7722826
                33293320
                e45311ba-cae9-40e2-a569-5eed3b4f51e9
                © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

                This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:  http://creativecommons.org/licenses/by-nc/4.0/.

                History
                : 08 June 2020
                : 31 October 2020
                : 19 November 2020
                Funding
                Funded by: Military Hospital 103, and Taipei Medical University;
                Award ID: 108-6202-008-112; 108-3805-022-400
                Categories
                Public Health
                1506
                2474
                1724
                Original research
                Custom metadata
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                Medicine
                epidemiology,public health,infection control,occupational & industrial medicine,anxiety disorders,depression & mood disorders

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