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      Growth Hormone Actions on Fat Distribution and Metabolism

      Hormone Research in Paediatrics

      S. Karger AG

      Fat distribution, Metabolism, Growth hormone

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          The secretion of growth hormone (GH) and the mass and distribution of body fat are linked through a complex series of interactions. There is increasing evidence that a GH/fat cycle exists and that elements of this cycle may possess regulatory functions. The essential elements of the cycle are: (1) GH-deficient individuals are often obese and lose body fat when they are treated; GH is lipolytic in vitro and causes an acute release of free fatty acids (FFA) when administered in vivo; (3) circulating FFA inhibit the pituitary release of GH by most secretagogues, including growth hormone releasing hormone, and (4) the obese state is characterized by a defect in GH release which can be reversed by weight loss.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          03 December 2008
          : 38
          : Suppl 2
          : 41-43
          Department of Pediatrics, Cornell University Medical College, New York, NY, USA
          182592 Horm Res 1992;38:41–43
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 3
          Anabolic and Metabolic Effects of Growth Hormone Action


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