Familial hypercholesterolaemia (FH) causes severe complications including cardiovascular diseases (CVDs) and stroke, leading to poor quality of life (QoL). Despite the availability of advanced treatment, data on QoL and its contributing factors is sparse. Hence, this study aimed to describe the pattern of QoL among FH patients and investigate its association with sociodemographic factors and illness characteristics. Hundred FH patients were assessed using Pro forma questionnaires and World Health Organization QoL questionnaire (WHOQOL-BREF). Significant contributing factors including level of education, income, and the presence and type of CVDs. These findings may help to inform more effective interventions for FH patients.