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      Parathyroid Hormone-Related Protein: Roles in the Glomerulus

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          Abstract

          Parathyroid hormone (PTH) and PTH-related protein (PTHrP) produce similar biological effects through the PTH/PTHrP receptor. Less is known about the physiological role of PTHrP which was first identified as the agent of the humoral hypercalcemia of malignancy. Despite the widespread production of PTHrP in healthy individuals, the concentration of the protein is below the detectable limit of current assays, suggesting that PTHrP normally functions locally in an autocrine or paracrine manner. Thus, some differences in their biological activities have been described, and they may be related to the presence of different receptors. In this regard, a second receptor which binds selectively to PTH has also been found. Recent studies have demonstrated the expression of both PTH/PTHrP receptor and protein in the renal glomeruli. Moreover, there are convincing data that support a direct role of PTH and PTHrP in modulating renal blood flow and glomerular filtration rate. This multifunctional protein, PTHrP, also has a proliferative effect on mesangial cells, supporting the notion that it may play a role in the normal glomerulus and in injured kidney.

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          Most cited references 2

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          Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.

          We have identified a G-protein-coupled receptor specifically activated by parathyroid hormone, which we refer to as the PTH2 receptor. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP, hypercalcemia of malignancy factor) activate a previously identified PTH/PTHrP receptor, which has a widespread tissue distribution. The PTH2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution. It is activated by PTH and not by PTHrP and is particularly abundant in the brain and pancreas.
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            Evidence for parathyroid hormone sensitive adenylate cyclase in rat glomeruli

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              Author and article information

              Journal
              EXN
              Nephron Exp Nephrol
              10.1159/issn.1660-2129
              Cardiorenal Medicine
              S. Karger AG
              1660-2129
              1999
              June 1999
              28 May 1999
              : 7
              : 3
              : 212-216
              Affiliations
              aDepartment of Physiology, Alcalá School of Medicine, University of Alcalá, Alcalá de Henares; bDivision of Nephrology, Príncipe de Asturias Hospital, Alcalá de Henares; cDepartment of Nephrology, Prínceps d’Espanya Hospital, L’Hospitalet de Llobregat, Barcelona, Spain
              Article
              20604 Exp Nephrol 1999;7:212–216
              10.1159/000020604
              10352361
              © 1999 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Tables: 1, References: 15, Pages: 5
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              Self URI (application/pdf): https://www.karger.com/Article/Pdf/20604
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