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      Parathyroid Hormone-Related Protein: Roles in the Glomerulus

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          Parathyroid hormone (PTH) and PTH-related protein (PTHrP) produce similar biological effects through the PTH/PTHrP receptor. Less is known about the physiological role of PTHrP which was first identified as the agent of the humoral hypercalcemia of malignancy. Despite the widespread production of PTHrP in healthy individuals, the concentration of the protein is below the detectable limit of current assays, suggesting that PTHrP normally functions locally in an autocrine or paracrine manner. Thus, some differences in their biological activities have been described, and they may be related to the presence of different receptors. In this regard, a second receptor which binds selectively to PTH has also been found. Recent studies have demonstrated the expression of both PTH/PTHrP receptor and protein in the renal glomeruli. Moreover, there are convincing data that support a direct role of PTH and PTHrP in modulating renal blood flow and glomerular filtration rate. This multifunctional protein, PTHrP, also has a proliferative effect on mesangial cells, supporting the notion that it may play a role in the normal glomerulus and in injured kidney.

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          Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.

          We have identified a G-protein-coupled receptor specifically activated by parathyroid hormone, which we refer to as the PTH2 receptor. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP, hypercalcemia of malignancy factor) activate a previously identified PTH/PTHrP receptor, which has a widespread tissue distribution. The PTH2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution. It is activated by PTH and not by PTHrP and is particularly abundant in the brain and pancreas.
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            Evidence for parathyroid hormone sensitive adenylate cyclase in rat glomeruli


              Author and article information

              Nephron Exp Nephrol
              Cardiorenal Medicine
              S. Karger AG
              June 1999
              28 May 1999
              : 7
              : 3
              : 212-216
              aDepartment of Physiology, Alcalá School of Medicine, University of Alcalá, Alcalá de Henares; bDivision of Nephrology, Príncipe de Asturias Hospital, Alcalá de Henares; cDepartment of Nephrology, Prínceps d’Espanya Hospital, L’Hospitalet de Llobregat, Barcelona, Spain
              20604 Exp Nephrol 1999;7:212–216
              © 1999 S. Karger AG, Basel

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              Page count
              Tables: 1, References: 15, Pages: 5
              Self URI (application/pdf): https://www.karger.com/Article/Pdf/20604


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