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      Electroretinogram of the Isolated Dog’s Head after Prolonged Complete Brain Ischemia

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      Ophthalmic Research

      S. Karger AG

      Isolated head, Dog, Electroretinogram, Brain ischemia

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          Abstract

          In experiments with 34 isolated dog heads, the electroretinogram (ERG) was registered at the beginning and after the end of complete normothermic brain ischemia lasting for 20, 30, 45 or 60 min. Compared with the EEG, the survival time of the ERG is significantly longer and the latency of recovery significantly shorter. Smaller but also significant differences persist even if the survival and reappearance of typical complex ERG configuration are evaluated. The greater resistance of the ERG against ischemia is explained if one assumes that the ERG is generated by different structures (individual layers of the retina and probably also surrouding nonneural tissues) which are less sensitive to oxygen deprivation than the brain cortex. The excessive values concerning the resistance of the ERG as given in the literature are partly due to the incompleteness of the ischemia and due to the concomitant evaluation of DC potantials.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1972
          July 2004
          09 December 2009
          : 4
          : 4
          : 237-245
          Affiliations
          Institute of Pathophysiology, Medical Faculty, Charles University, Plzeñ, and Institut für Normale und Pathologische Physiologie der Universität, Köln
          Article
          265990 Ophthalmic Res 1972–73;4:237–245
          10.1159/000265990
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Paper

          Vision sciences, Ophthalmology & Optometry, Pathology

          Isolated head, Dog, Brain ischemia, Electroretinogram

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