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      Mechanisms of Caloric Restriction-Mediated Stress-Resistance in Acute Kidney Injury

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          Abstract

          Caloric restriction (CR)-mediated organ protection has been shown to be extremely efficient in rodent models of acute kidney injury (AKI). Limited understanding of the underlying mechanisms paired with a risk of malnourishment and feasibility problems has hindered the translation of this immense potential to the patient setting. In this mini-review, the current mechanistic concepts of CR-mediated stress-resistance as potential key targets for renal protection in AKI will be highlighted.

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          Most cited references21

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          Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection

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            Augmenting autophagy to treat acute kidney injury during endotoxemia in mice

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              The role of the mammalian target of rapamycin (mTOR) in renal disease

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                Author and article information

                Journal
                NEF
                Nephron
                10.1159/issn.1660-8151
                Nephron
                S. Karger AG
                1660-8151
                2235-3186
                2022
                May 2022
                02 August 2021
                : 146
                : 3
                : 234-238
                Affiliations
                [_a] aDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
                [_b] bCECAD, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
                Author information
                https://orcid.org/0000-0001-6910-0745
                Article
                517733 Nephron 2022;146:234–238
                10.1159/000517733
                34340234
                e47e1104-12cc-4989-a245-42881dce7326
                © 2021 The Author(s). Published by S. Karger AG, Basel

                This article is licensed under the Creative Commons Attribution 4.0 International License (CC BY). Usage, derivative works and distribution are permitted provided that proper credit is given to the author and the original publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                : 15 April 2021
                : 07 June 2021
                Page count
                Figures: 1, Pages: 5
                Categories
                Clinical Practice: Mini-Review

                Cardiovascular Medicine,Nephrology
                Stress-resistance,Caloric restriction,Acute kidney injury,Dietary preconditioning,Mechanisms

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