For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
3
views
80
references
 Top references
cited by
20
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      48
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Viral transport and the cytoskeleton

      review-article
      Author(s): a , a , *
      Publication date (Electronic):
      Journal: Current Opinion in Cell Biology
      Publisher: Elsevier Science Ltd.
      Keywords: Cytoskeleton, Virus, Actin, Microtubules, Transport, Motility

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In the past decade, studies into the way in which intracellular bacterial pathogens hijack and subvert their hosts have provided many important insights into regulation of the actin cytoskeleton and cell motility, in addition to increasing our understanding of the infection process. Viral pathogens, however, may ultimately unlock more cellular secrets as they are even more dependent on their hosts during their life cycle.

          Related collections

          Most cited references80

          • Record: found
          • Abstract: found
          • Article: not found

          Microtubule-mediated Transport of Incoming Herpes Simplex Virus 1 Capsids to the Nucleus

          Beate Sodeik, Melanie Ebersold, Ari Helenius (1997)
          Herpes simplex virus 1 fuses with the plasma membrane of a host cell, and the incoming capsids are efficiently and rapidly transported across the cytosol to the nuclear pore complexes, where the viral DNA genomes are released into the nucleoplasm. Using biochemical assays, immunofluorescence, and immunoelectron microscopy in the presence and absence of microtubule depolymerizing agents, it was shown that the cytosolic capsid transport in Vero cells was mediated by microtubules. Antibody labeling revealed the attachment of dynein, a minus end–directed, microtubule-dependent motor, to the viral capsids. We propose that the incoming capsids bind to microtubules and use dynein to propel them from the cell periphery to the nucleus.
          Article 0 comments Cited 128 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling.

            F Frischknecht, V Moreau, S Röttger … (1999)
            Studies of the actin-based motility of the intracellular pathogens Listeria monocytogenes and Shigella flexneri have provided important insight into the events occurring at the leading edges of motile cells. Like the bacteria Listeria and Shigella, vaccinia virus, a relative of the causative agent of smallpox, uses actin-based motility to spread between cells. In contrast to Listeria or Shigella, the actin-based motility of vaccinia is dependent on an unknown phosphotyrosine protein, but the underlying mechanism remains obscure. Here we show that phosphorylation of tyrosine 112 in the viral protein A36R by Src-family kinases is essential for the actin-based motility of vaccinia. Tyrosine phosphorylation of A36R results in a direct interaction with the adaptor protein Nck and the recruitment of the Ena/VASP family member N-WASP to the site of actin assembly. We also show that Nck and N-WASP are essential for the actin-based motility of vaccinia virus. We suggest that vaccinia virus spreads by mimicking the signalling pathways that are normally involved in actin polymerization at the plasma membrane.
            Article 0 comments Cited 87 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Microtubule-dependent Plus- and Minus End–directed Motilities Are Competing Processes for Nuclear Targeting of Adenovirus

              Maarit Suomalainen, Michel Nakano, Stephan S. Keller … (1999)
              Adenovirus (Ad) enters target cells by receptor-mediated endocytosis, escapes to the cytosol, and then delivers its DNA genome into the nucleus. Here we analyzed the trafficking of fluorophore-tagged viruses in HeLa and TC7 cells by time-lapse microscopy. Our results show that native or taxol-stabilized microtubules (MTs) support alternating minus- and plus end–directed movements of cytosolic virus with elementary speeds up to 2.6 μm/s. No directed movement was observed in nocodazole-treated cells. Switching between plus- and minus end–directed elementary speeds at frequencies up to 1 Hz was observed in the periphery and near the MT organizing center (MTOC) after recovery from nocodazole treatment. MT-dependent motilities allowed virus accumulation near the MTOC at population speeds of 1–10 μm/min, depending on the cell type. Overexpression of p50/dynamitin, which is known to affect dynein-dependent minus end–directed vesicular transport, significantly reduced the extent and the frequency of minus end–directed migration of cytosolic virus, and increased the frequency, but not the extent of plus end–directed motility. The data imply that a single cytosolic Ad particle engages with two types of MT-dependent motor activities, the minus end– directed cytoplasmic dynein and an unknown plus end– directed activity.
              Article 0 comments Cited 86 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Michael Way
                Journal
                Journal ID (nlm-ta): Curr Opin Cell Biol
                Journal ID (iso-abbrev): Curr. Opin. Cell Biol
                Title: Current Opinion in Cell Biology
                Publisher: Elsevier Science Ltd.
                ISSN (Print): 0955-0674
                ISSN (Electronic): 1879-0410
                Publication date PMC-release: 9 January 2001
                Publication date (Print): 1 February 2001
                Publication date (Electronic): 9 January 2001
                Volume: 13
                Issue: 1
                Pages: 97-105
                Affiliations
                [a ]European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
                Author notes
                [* ]Corresponding author. way@ 123456embl-heidelberg.de
                Article
                Publisher ID: S0955-0674(00)00180-0
                DOI: 10.1016/S0955-0674(00)00180-0
                PMC ID: 7125730
                PubMed ID: 11163140
                SO-VID: e47e8962-750f-4cac-acd9-a5cb7e1f5d0d
                Copyright statement: Copyright © 2001 Elsevier Science Ltd. All rights reserved.
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                Categories
                Subject: Article

                ScienceOpen disciplines: Cell biology
                Keywords: cytoskeleton,virus,actin,microtubules,transport,motility
                Data availability:
                ScienceOpen disciplines: Cell biology
                Keywords: cytoskeleton, virus, actin, microtubules, transport, motility

                Comments

                Comment on this article

                scite_

                Similar content48

                See all similar

                Cited by19

                See all cited by

                Most referenced authors920

                See all reference authors