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      Role of Ovarian Hormones in the Long-Term Control of Glucose Homeostasis


      Hormone Research in Paediatrics

      S. Karger AG

      Ovariectomy, Oestradiol, Progesterone, Glucose homeostasis, Insulin, Glucagon, Epinephrine

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          This study examines the effects of ovarian hormones on the glycaemic actions of insulin, glucagon and epinephrine. Ovariectomized adult female mice were treated with replacement doses of oestradiol, progesterone, both hormones combined or vehicle only for 15 weeks. Compared with intact control mice, ovariectomy did not significantly alter insulin-induced hypoglycaemia. However, treatment with oestradiol or progesterone alone, but not in combination, increased the hypoglycaemic action of insulin. The hyperglycaemic effect of glucagon and epinephrine was increased by ovariectomy and reduced by the ovarian hormone treatments. The results indicate that oestradiol and progesterone individually synergize the hypoglycaemic action of insulin, but mutually antagonize each other in this respect. Oestradiol and progesterone, individually and in combination, appear to suppress the glycogenolytic action of glucagon and epinephrine.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          10 December 2008
          : 13
          : 6
          : 396-403
          Department of Biological Sciences, University of Aston in Birmingham, Birmingham, UK
          179307 Horm Res 1980;13:396–403
          © 1980 S. Karger AG, Basel

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          Page count
          Pages: 8
          Original Paper


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