0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Role of Ovarian Hormones in the Long-Term Control of Glucose Homeostasis

      ,

      Hormone Research in Paediatrics

      S. Karger AG

      Ovariectomy, Oestradiol, Progesterone, Glucose homeostasis, Insulin, Glucagon, Epinephrine

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This study examines the effects of ovarian hormones on the glycaemic actions of insulin, glucagon and epinephrine. Ovariectomized adult female mice were treated with replacement doses of oestradiol, progesterone, both hormones combined or vehicle only for 15 weeks. Compared with intact control mice, ovariectomy did not significantly alter insulin-induced hypoglycaemia. However, treatment with oestradiol or progesterone alone, but not in combination, increased the hypoglycaemic action of insulin. The hyperglycaemic effect of glucagon and epinephrine was increased by ovariectomy and reduced by the ovarian hormone treatments. The results indicate that oestradiol and progesterone individually synergize the hypoglycaemic action of insulin, but mutually antagonize each other in this respect. Oestradiol and progesterone, individually and in combination, appear to suppress the glycogenolytic action of glucagon and epinephrine.

          Related collections

          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1980
          1980
          10 December 2008
          : 13
          : 6
          : 396-403
          Affiliations
          Department of Biological Sciences, University of Aston in Birmingham, Birmingham, UK
          Article
          179307 Horm Res 1980;13:396–403
          10.1159/000179307
          7024081
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Original Paper

          Comments

          Comment on this article