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      Isoniazid-Induced Crescentic Glomerulonephritis in a Child with a Positive Tuberculin Skin Test

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          Acute nonoliguric renal failure developed in a 13-year-old girl, 1 month after the institution of isoniazid therapy because of a positive tuberculin test at school screening. A renal biopsy demonstrated severe crescentic glomerulonephritis with focal interstitial changes. Discontinuation of isoniazid and a short course of steroids and cyclophosphamide therapy were followed by complete recovery. Whereas isoniazid has been shown to induce a lupus-like syndrome and antihistone antinuclear antibodies, our patient displayed none of the clinical or immunological features that are characteristic of drug-induced lupus. Furthermore, none of the identifiable causes for crescentic glomerulonephritis was evident in this girl. To the best of our knowledge this is the first report suggesting a possible association of crescentic glomerulonephritis to isoniazid treatment.

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          Author and article information

          Am J Nephrol
          American Journal of Nephrology
          S. Karger AG
          October 1998
          10 September 1998
          : 18
          : 5
          : 430-432
          a Division of Pediatrics, b Division of Pathology, and c Department of Nephrology, Rambam Medical Center and Technion, Faculty of Medicine, Haifa, Israel
          13389 Am J Nephrol 1998;18:430–432
          © 1998 S. Karger AG, Basel

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          Figures: 1, References: 10, Pages: 3
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