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      Augmented Plasma Protein C Activity after Coronary Thrombolysis with Urokinase in Patients with Acute Myocardial Infarction

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          Abstract

          Coronary thrombolysis reduces morbidity and mortality in patients with acute myocardial infarction, however, the exact effects of thrombolytic agents on the status of intrinsic hemos-tases are not fully understood. In the present study, we examined serial changes in plasma thrombin and protein C activities of 6 patients with acute myocardial infarction treated with urokinase. Fibrinolysis occurred immediately after urokinase injection with an increase in the plasma thrombin-antithrom-bin III complex, suggesting a subsequent procoagulant state due to thrombin generation. Correspondent increases in plasma protein C activity were observed, however, protein S levels did not change at all. Our findings suggest that urokinase administration for coronary thrombolysis not only causes fibrinolysis, but also induces thrombin activity, which may be antagonized by augmented intrinsic protein C activity.

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          Author and article information

          Journal
          Journal ID (publisher-id): CRD
          Journal ID (nlm-ta): Cardiology
          Journal ID (doi): 10.1159/issn.0008-6312
          Title: Cardiology
          Publisher: S. Karger AG
          ISSN (Print): 0008-6312
          ISSN (Electronic): 1421-9751
          Publication date Subscription-year: 1992
          Publication date (Print): 1992
          Publication date (Electronic): 12 November 2008
          Volume: 80
          Issue: 3-4
          Pages: 252-256
          Affiliations
          aCardiopulmonary Division and bDivision of Hematology, Department of Medicine, cDepartment of Laboratory Medicine, and dDepartment of Emergency Medicine, Keio University School of Medicine, Tokyo, Japan
          Article
          Publisher ID: 175010 Other ID: Cardiology 1992;80:252–256
          DOI: 10.1159/000175010
          PubMed ID: 1387346
          SO-VID: e4a7b9e1-7c64-4088-90ec-a81f9628351e
          Copyright © © 1992 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 27 February 1992
          Date accepted : 29 February 1992
          Page count
          Pages: 5
          Categories
          Subject: Coronary Care

          ScienceOpen disciplines: General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Keywords: Protein C,Coronary thrombolysis,Urokinase,Protein S,Myocardial infarction
          Data availability:
          ScienceOpen disciplines: General medicine, Neurology, Cardiovascular Medicine, Internal medicine, Nephrology
          Keywords: Protein C, Coronary thrombolysis, Urokinase, Protein S, Myocardial infarction

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