Augmented Plasma Protein C Activity after Coronary Thrombolysis with Urokinase in Patients with Acute Myocardial Infarction

Abstract

Coronary thrombolysis reduces morbidity and mortality in patients with acute myocardial infarction, however, the exact effects of thrombolytic agents on the status of intrinsic hemos-tases are not fully understood. In the present study, we examined serial changes in plasma thrombin and protein C activities of 6 patients with acute myocardial infarction treated with urokinase. Fibrinolysis occurred immediately after urokinase injection with an increase in the plasma thrombin-antithrom-bin III complex, suggesting a subsequent procoagulant state due to thrombin generation. Correspondent increases in plasma protein C activity were observed, however, protein S levels did not change at all. Our findings suggest that urokinase administration for coronary thrombolysis not only causes fibrinolysis, but also induces thrombin activity, which may be antagonized by augmented intrinsic protein C activity.

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1992

Publication date (Print): 1992

Publication date (Electronic): 12 November 2008

Volume: 80

Issue: 3-4

Pages: 252-256

Affiliations

^aCardiopulmonary Division and ^bDivision of Hematology, Department of Medicine, ^cDepartment of Laboratory Medicine, and ^dDepartment of Emergency Medicine, Keio University School of Medicine, Tokyo, Japan

Article

Publisher ID: 175010 Other ID: Cardiology 1992;80:252–256

DOI: 10.1159/000175010

PubMed ID: 1387346

Copyright statement: © 1992 S. Karger AG, Basel

License:

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Page count

Pages: 5

Product

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Categories

Subject: Coronary Care