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      The Role of Calcium in Glucagon Release

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          The interrelationship between arginine and calcium in glucagon release was studied using the in vitro perfused rat pancreas. In the presence of a normal 2 m M calcium concentration, 10 m M arginine provoked biphasic glucagon release, the amplitude of such a response being inversely related to the glucose concentration of the perfusate. At the lowest 3.3 m M glucose concentration, and after prolonged (40 min) as well as short (10 min) periods of calcium deprivation, arginine-induced glucagon release was inhibited. These results clearly indicate that calcium is necessary for either the recognition or effectiveness of arginine as a stimulus to the α-cell. Taking into account this, as well as other data presently available in the literature, it is suggested that calcium plays a versatile role – permissive, inhibitory and stimulatory – in glucagon secretion. The intimate mechanisms by which calcium exerts such versatile actions in the α-cell remain to be elucidated.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 7
          : 6
          : 348-362
          Laboratory of Experimental Medicine, Université Libre de Bruxelles, Bruxelles
          178749 Horm Res 1976;7:348–362
          © 1976 S. Karger AG, Basel

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          Pages: 15


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