The Role of Calcium in Glucagon Release

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Abstract

The interrelationship between arginine and calcium in glucagon release was studied using the in vitro perfused rat pancreas. In the presence of a normal 2 m M calcium concentration, 10 m M arginine provoked biphasic glucagon release, the amplitude of such a response being inversely related to the glucose concentration of the perfusate. At the lowest 3.3 m M glucose concentration, and after prolonged (40 min) as well as short (10 min) periods of calcium deprivation, arginine-induced glucagon release was inhibited. These results clearly indicate that calcium is necessary for either the recognition or effectiveness of arginine as a stimulus to the α-cell. Taking into account this, as well as other data presently available in the literature, it is suggested that calcium plays a versatile role – permissive, inhibitory and stimulatory – in glucagon secretion. The intimate mechanisms by which calcium exerts such versatile actions in the α-cell remain to be elucidated.

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Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1976

Publication date (Print): 1976

Publication date (Electronic): 25 November 2008

Volume: 7

Issue: 6

Pages: 348-362

Affiliations

Laboratory of Experimental Medicine, Université Libre de Bruxelles, Bruxelles

Article

Publisher ID: 178749 Other ID: Horm Res 1976;7:348–362

DOI: 10.1159/000178749

PubMed ID: 1028726

SO-VID: e4ad8056-3fde-4e6f-b914-d7000ab1ddef

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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Pages: 15

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