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      Evaluate Efficacy of Desensitizing Toothpaste Containing Zinc-carbonate Hydroxyapatite Nanocrystals: Non-comparative Eight-week Clinical Study

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          Abstract

          Objective:

          The aim of the study was to evaluate the clinical effectiveness of desensitizing toothpaste in reducing the dentine hypersensitivity (DH).

          Materials and Methods:

          The study was a before and after clinical trial conducted to evaluate the clinical efficacy of a desensitizing toothpaste containing zinc-carbonate hydroxyapatite nanocrystals (Zn-CHA) for controlling DH. The trial involved 72 patients with DH who were evaluated four and eight weeks after using Zn-CHA toothpaste. The sensitivity was assessed by airblast method using Schiff Sensitivity Scale.

          Results:

          Repeated measures analysis of variance test was used to compare baseline score with fourth and eighth week. Statistically significant differences were observed between sensitivity scores at baseline and those at four- and eight-week intervals ( P < 0.001).

          Conclusion:

          The results suggested that the use of Zn-CHA nanocrystals dentifrice might become an effective therapy to reduce DH.

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          Most cited references26

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          A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice.

          Several dentifrices have shown to be effective in reducing dentine hypersensitivity (DH), but more effective products are needed. The aim of the study was to evaluate the desensitizing efficacy of a new dentifrice based on zinc-carbonate hydroxyapatite (CHA) nanocrystals. Using a double-blind, randomized design, the new dentifrice was compared with potassium nitrate/fluoride dentifrice (active control). The participant's DH was evaluated at baseline and after 4 and 8 weeks using airblast (primary outcome), tactile, cold water and subjective tests (secondary outcomes). The final sample consisted of 70 subjects with baseline DH; 36 received the new dentifrice and 34 the control one. Both dentifrices were largely effective; the percentage of score reduction from baseline to 8 weeks was greater than 28% for all tests (and greater than 55% for the cold water test) in both groups. As compared with controls, experimental subjects had a significantly greater improvement in the airblast test score (mean percentage of reduction of 46.0%versus 29.4% in controls) and the subjective test score (47.5%versus 28.1%, respectively), with both differences already being significant after 4 weeks. In contrast, there was no significant difference between groups for either the tactile or cold water tests at any time point and with any outcome. This study documented that the new dentifrice containing zinc-CHA nanocrystals significantly reduced dentinal hypersensitivity after 4 and 8 weeks, supporting its utility in clinical practice.
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            A cross-sectional study of buccal cervical sensitivity in UK general dental practice and a summary review of prevalence studies.

            The initial aim of this study was to establish the prevalence of dentine hypersensitivity (DH) in a cross-sectional study of patients visiting general dental practitioners in the UK over a period of one calendar month. Eighteen dental practitioners examined 5,477 patients over a period of one calendar month, and patients who were diagnosed with DH were questioned further about their occupation and smoking habits. The amount of buccal gingival recession associated with the sensitive teeth was also recorded, as was the presence of periodontal disease. One hundred and fifty-two patients were diagnosed as having DH, giving a prevalence figure of 2.8%. The commonest teeth affected were the first molars and premolars, and the commonest initiating factor was cold drinks. A tendency for a greater number of DH teeth was also found for patients with periodontal disease who also smoked. There was also a tendency for the patients with DH teeth to come from higher social groups. At the time of conducting this study, the European Federation of Periodontology had not recommended that sensitive teeth associated with periodontal disease and treatment be termed root sensitivity (RS). The title of this paper was therefore chosen to reflect this decision, and the data represent teeth both within and between subjects with DH and RS.
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              Materials science. A window on biomineralization.

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                Author and article information

                Journal
                J Int Soc Prev Community Dent
                J Int Soc Prev Community Dent
                JISPCD
                Journal of International Society of Preventive & Community Dentistry
                Wolters Kluwer - Medknow (India )
                2231-0762
                2250-1002
                Nov-Dec 2019
                25 October 2019
                : 9
                : 6
                : 566-570
                Affiliations
                [1]Department of Periodontics and Oral Medicine, College of Dentistry, Qassim University, Buraidah, Kingdom Saudi Arabia
                Author notes
                Address for correspondence: Dr. Muhammad K. Khan, Department of Periodontics and Oral Medicine, College of Dentistry, Qassim University, Kingdom of Saudi Arabia. E-mail: dr.muhammad.kahlil@ 123456qudent.edu.sa
                Article
                JISPCD-9-566
                10.4103/jispcd.JISPCD_261_19
                6905321
                32039076
                e4af3328-e4a2-4279-9849-9719b789167b
                Copyright: © 2019 Journal of International Society of Preventive and Community Dentistry

                This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

                History
                : 13 June 2019
                : 26 September 2019
                Categories
                Original Article

                biorepair sensitive toothpaste,clinical trial,dentine hypersensitivity,schiff sensitivity scale,zinc-carbonate hydroxyapatite nanocrystals

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