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Potentiation of Antitumor Activity of Macrophages by Recombinant Interferon Alpha A/D Contained in Gelatin Microspheres

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      Abstract

      Gelatin microspheres containing recombinant human interferon αA/D (A/D‐IFN) (IFN‐microspheres) potentiated the antitumor activity of mouse peritoneal macrophages (Mφo) much more efficiently than free A/D‐IFN. Mφo acquired the inhibitory activity on tumor cell growth by the ingestion of IFN‐microspheres without the aid of lipopolysaccharide (LPS), though LPS was required as a second signal for activating Mφo primed with free IFN. The IFN‐microspheres were much more efficient than free IFN plus LFS in respect of the IFN amount and the time required for Mφo activation. Furthermore, Mφo pretreated with the IFN‐microspheres maintained their activated state for a much longer period than those pretreated with free A/D‐IFN plus LPS. A monoclonal anti‐IFN‐αA antibody, which was capable of neutralizing A/D‐IFN, did not interfere with the Mφo activation by the IFN‐microspheres. Even human IFN‐αA was effective in activating murine Mφo similarly to A/D‐IFN, when given in the form of IFN‐microspheres, though human IFN‐αA in the free form was ineffective. These results argue that the mechanism of Mφo activation by the IFN‐microspheres is different from that by free IFN.

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      Most cited references 33

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      THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

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        Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.

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          The 3-Methyl-2-benzothiazolone Hydrazone Test. Sensitive New Methods for the Detection, Rapid Estimation, and Determination of Aliphatic Aldehydes

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            Author and article information

            Affiliations
            [ 1 ]Research Center for Medical Polymers and Biomaterials, Kyoto University, 53, Kawahara‐cho, Shogoin, Sakyo‐ku, Kyoto 606
            [ 2 ]Department of Zoology, Faculty of Science, Kyoto University, Kitashirakawa‐Oiwake‐cho, Sakyo‐ku, Kyoto 606
            [ 3 ]Kyoto Pasteur Institute, 425, Yamamoto‐cho, Gokomachi‐dori, Oshikoji‐agaru, Nakagyo‐ku, Kyoto 604
            Journal
            Jpn J Cancer Res
            Jpn. J. Cancer Res
            10.1111/(ISSN)1349-7006a
            CAS
            Japanese Journal of Cancer Research : Gann
            Blackwell Publishing Ltd (Oxford, UK )
            0910-5050
            1876-4673
            May 1988
            : 79
            : 5 ( doiID: 10.1111/cas.1988.79.issue-5 )
            : 636-646
            3136117
            5917552
            10.1111/j.1349-7006.1988.tb00034.x
            CAE636
            Counts
            References: 35, Pages: 11
            Product
            Categories
            Article
            Custom metadata
            2.0
            May 1988
            Converter:WILEY_ML3GV2_TO_NLMPMC version:4.6.9 mode:remove_FC converted:04.11.2015

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