Blog
About

3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Potentiation of Antitumor Activity of Macrophages by Recombinant Interferon Alpha A/D Contained in Gelatin Microspheres

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Gelatin microspheres containing recombinant human interferon αA/D (A/D‐IFN) (IFN‐microspheres) potentiated the antitumor activity of mouse peritoneal macrophages (Mφo) much more efficiently than free A/D‐IFN. Mφo acquired the inhibitory activity on tumor cell growth by the ingestion of IFN‐microspheres without the aid of lipopolysaccharide (LPS), though LPS was required as a second signal for activating Mφo primed with free IFN. The IFN‐microspheres were much more efficient than free IFN plus LFS in respect of the IFN amount and the time required for Mφo activation. Furthermore, Mφo pretreated with the IFN‐microspheres maintained their activated state for a much longer period than those pretreated with free A/D‐IFN plus LPS. A monoclonal anti‐IFN‐αA antibody, which was capable of neutralizing A/D‐IFN, did not interfere with the Mφo activation by the IFN‐microspheres. Even human IFN‐αA was effective in activating murine Mφo similarly to A/D‐IFN, when given in the form of IFN‐microspheres, though human IFN‐αA in the free form was ineffective. These results argue that the mechanism of Mφo activation by the IFN‐microspheres is different from that by free IFN.

          Related collections

          Most cited references 33

          • Record: found
          • Abstract: not found
          • Article: not found

          THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              The 3-Methyl-2-benzothiazolone Hydrazone Test. Sensitive New Methods for the Detection, Rapid Estimation, and Determination of Aliphatic Aldehydes

                Bookmark

                Author and article information

                Affiliations
                [ 1 ]Research Center for Medical Polymers and Biomaterials, Kyoto University, 53, Kawahara‐cho, Shogoin, Sakyo‐ku, Kyoto 606
                [ 2 ]Department of Zoology, Faculty of Science, Kyoto University, Kitashirakawa‐Oiwake‐cho, Sakyo‐ku, Kyoto 606
                [ 3 ]Kyoto Pasteur Institute, 425, Yamamoto‐cho, Gokomachi‐dori, Oshikoji‐agaru, Nakagyo‐ku, Kyoto 604
                Journal
                Jpn J Cancer Res
                Jpn. J. Cancer Res
                10.1111/(ISSN)1349-7006a
                CAS
                Japanese Journal of Cancer Research : Gann
                Blackwell Publishing Ltd (Oxford, UK )
                0910-5050
                1876-4673
                May 1988
                : 79
                : 5 ( doiID: 10.1111/cas.1988.79.issue-5 )
                : 636-646
                CAE636
                10.1111/j.1349-7006.1988.tb00034.x
                5917552
                3136117
                Counts
                References: 35, Pages: 11
                Product
                Categories
                Article
                Custom metadata
                2.0
                May 1988
                Converter:WILEY_ML3GV2_TO_NLMPMC version:4.6.9 mode:remove_FC converted:04.11.2015

                Comments

                Comment on this article