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      Influence of Locally Altered in vivo Shear Stress on Aortic Histamine-Forming Capacity and Aortic Albumin Uptake

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          Effects of locally elevated shear stresses on thoracic aortic histamine formation and transmural albumin uptake have been examined under in vivo conditions in anesthetized male, mongrel dogs. Results indicate that if endothelium remains intact, significant linear relationships exist between the shear intensity and aortic histamine-forming capacity and aortic content of fluorescein-labeled bovine serum albumin following 20 h of circulation time. These data suggest that in vivo the aortic (and endothelial) histidine decarboxylase system is sensitive to local alterations in applied shear stress, and that de novo aortic histamine synthesis is involved in mediating shear-induced increases in aortic transmural permeability.

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          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 18
          : 1-2
          : 45-57
          Department of Biology, Pennsylvania State University, University Park, Pa., USA
          158337 Blood Vessels 1981;18:45–57
          © 1981 S. Karger AG, Basel

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          Pages: 13
          Research Paper


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