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Extension of donor lung preservation with hypothermic storage after normothermic ex vivo lung perfusion
Michael Kuan Yew Hsin ,
Ilker Iskender ,
Daisuke Nakajima ,
Manyin Chen ,
Hyunhee Kim ,
Pedro Reck dos Santos ,
Jin Sakamoto ,
Jingu Lee ,
Kohei Hashimoto ,
Constantine Harmantas ,
David Hwang ,
Tom Waddell ,
Mingyao Liu ,
Shaf Keshavjee ,
Marcelo Cypel
January 2016
January 2016
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Abstract
Ex vivo lung perfusion (EVLP) allows normothermic evaluation and treatment of donor
lungs not currently acceptable for transplant and improves organ use. Donor lungs
undergo a period of cold preservation before (cold ischemic time [CIT]-1) and after
(CIT-2) EVLP. We investigated the effect of an extended CIT-2 on lung function after
transplantation.