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      Influence of Papaverine and Nitrite on the Responses to Norepinephrine of Inner and Outer Smooth Muscle of Sheep Carotid Arteries


      Journal of Vascular Research

      S. Karger AG

      Vasodilators, Carotid arteries, Smooth muscle, Papaverine, Nitrite, Norepinephrine, Calcium

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          Inner muscle of sheep carotid arteries responded to norepinephrine in lower concentration, and with a larger initial contraction, than outer muscle. Initial contractions of both tissues did not require external Ca but stable contractions did. Papaverine greatly depressed stable but not initial contractions, causing inner muscle to respond to each effective concentration of norepinephrine by contraction followed by relaxation. Papaverine particularly depressed the stable responses of inner muscle to low concentrations of norepinephrine. Nitrite generally caused changes in response qualitatively similar to those produced by papaverine.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 11
          : 4
          : 229-240
          Department of Physiology, London Hospital Medical College, London
          158016 Blood Vessels 1974;11:229–240
          © 1974 S. Karger AG, Basel

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          Page count
          Pages: 12
          Research Paper


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