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      Influence of Papaverine and Nitrite on the Responses to Norepinephrine of Inner and Outer Smooth Muscle of Sheep Carotid Arteries

      ,

      Journal of Vascular Research

      S. Karger AG

      Vasodilators, Carotid arteries, Smooth muscle, Papaverine, Nitrite, Norepinephrine, Calcium

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          Abstract

          Inner muscle of sheep carotid arteries responded to norepinephrine in lower concentration, and with a larger initial contraction, than outer muscle. Initial contractions of both tissues did not require external Ca but stable contractions did. Papaverine greatly depressed stable but not initial contractions, causing inner muscle to respond to each effective concentration of norepinephrine by contraction followed by relaxation. Papaverine particularly depressed the stable responses of inner muscle to low concentrations of norepinephrine. Nitrite generally caused changes in response qualitatively similar to those produced by papaverine.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1974
          1974
          18 September 2008
          : 11
          : 4
          : 229-240
          Affiliations
          Department of Physiology, London Hospital Medical College, London
          Article
          158016 Blood Vessels 1974;11:229–240
          10.1159/000158016
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Research Paper

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