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      Immunosenescence of Polymorphonuclear Neutrophils

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          Abstract

          All immune cells are affected by aging, contributing to the high susceptibility to infections and increased mortality observed in the elderly. The effect of aging on cells of the adaptive immune system is well documented. In contrast, knowledge concerning age-related defects of polymorphonuclear neutrophils (PMN) is limited. During the past decade, it has become evident that in addition to their traditional role as phagocytes, neutrophils are able to secrete a wide array of immunomodulating molecules. Their importance is underlined by the finding that genetic defects that lead to neutropenia increase susceptibility to infections. Whereas there is consistence about the constant circulating number of PMN throughout aging, the abilities of tissue infiltration, phagocytosis, and oxidative burst of PMN from aged donors are discussed controversially. Furthermore, there are numerous discrepancies between in vivo and in vitro results, as well as between results for murine and human PMN. Most of the reported functional changes can be explained by defective signaling pathways, but further research is required to get a detailed insight into the underlying molecular mechanisms. This could form the basis for drug development in order to prevent or treat age-related diseases, and thus to unburden the public health systems.

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          Author and article information

          Journal
          ScientificWorldJournal
          ScientificWorldJournal
          TSWJ
          The Scientific World Journal
          TheScientificWorldJOURNAL
          2356-6140
          1537-744X
          2010
          21 January 2010
          : 10
          : 145-160
          Affiliations
          Institute of Immunology, Medical Faculty RWTH Aachen University, Germany
          Author notes

          Academic Editor: Olivia M. Pereira-Smith

          Article
          862098
          10.1100/tsw.2010.14
          5763979
          20098958
          e4ee15c9-0960-4ccc-b68e-bd8470f05898
          Copyright © 2010 Inga Wessels et al.

          This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

          History
          : 5 October 2009
          : 18 December 2009
          : 21 December 2009
          Categories
          Mini-Review Article

          Uncategorized
          neutrophils,polymorphonuclear neutrophils,immunosenescence,inflammaging,aging,elderly,senieur protocol,adhesion,polymorphonuclear leukocytes,phagocytosis,chemotaxis,degranulation,intracellular killing,inflammation,apoptosis,g-csf,gm-csf,fmlp,toll-like receptor,triggering receptor expressed on myeloid cells,signaling,membrane fluidity

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