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      Black raspberries and their anthocyanin and fiber fractions alter the composition and diversity of gut microbiota in F-344 rats

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          Abstract

          Natural compounds can alter the diversity and composition of the gut microbiome, potentially benefiting our health. We previously demonstrated chemopreventive effects of black raspberries (BRBs) in colorectal cancer, which associates with gut dysbiosis. To investigate the effects of whole BRBs and their fractions on gut microbiota, we fed F-344 rats a control diet, 5% BRBs, the BRB anthocyanin fraction, or the BRB residue fraction for 6 weeks. Feces were collected at baseline and at weeks 3 and 6, and bacterial sequence counts were analyzed. We observed distinct patterns of microbiota from different diet groups. Beta diversity analysis suggested that all diet groups exerted time-dependent changes in the bacterial diversity. Hierarchical clustering analysis revealed that post-diet fecal microbiota was segregated from baseline fecal microbiota within each diet. It is interesting to note that fractions of BRBs induced different changes in gut bacteria compared to whole BRBs. The abundance of specific microbial species known to have anti-inflammatory effects, such as Akkermansia and Desulfovibrio, was increased by whole BRBs and their residue. Further, butyrate-producing bacteria, e.g., Anaerostipes, were increased by whole BRBs. Our results suggest that whole BRBs and their fractions alter the gut microbiota in ways that could significantly impact human health.

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          Author and article information

          Journal
          7905040
          6142
          Nutr Cancer
          Nutr Cancer
          Nutrition and cancer
          0163-5581
          1532-7914
          9 September 2018
          18 July 2017
          Aug-Sep 2017
          16 September 2018
          : 69
          : 6
          : 943-951
          Affiliations
          [1 ]Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. ppan@ 123456mcw.edu
          [2 ]Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI, USA. vylam03@ 123456gmail.com
          [3 ]Department of Pediatrics/Gastroenterology, Medical College of Wisconsin, Milwaukee, WI, USA. nsalzman@ 123456mcw.edu
          [4 ]Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA. ywhuang@ 123456mcw.edu
          [5 ]Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA. Jianhua.yu@ 123456osumc.edu
          [6 ]Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA. jianying.zhang@ 123456osumc.edu
          Author notes
          [* ] Corresponding author: Li-Shu Wang, Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin Rm C4930, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA. liswang@ 123456mcw.edu , Phone: 414-955-2827, Fax: 414-955-6059
          Article
          PMC6139254 PMC6139254 6139254 nihpa988306
          10.1080/01635581.2017.1340491
          6139254
          28718724
          e5071152-55c7-4358-96a5-55bbbb2c08af
          History
          Categories
          Article

          anthocyanins,Black raspberries,fiber,gut microbiota
          anthocyanins, Black raspberries, fiber, gut microbiota

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