12
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      A Uniform System For The Annotation Of Human microRNA Genes And The Evolution Of The Human microRNAome

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Although microRNAs (miRNAs) are among the most intensively studied molecules of the past 20 years, determining what is and what is not a miRNA has not been straightforward. Here, we present a uniform system for the annotation and nomenclature of miRNA genes. We show that fewer than a third of the 1,881 human miRBase entries, and only approximately 16% of the 7,095 metazoan miRBase entries, are robustly supported as miRNA genes. Furthermore, we show that the human repertoire of miRNAs has been shaped by periods of intense miRNA innovation, and that mature gene products show a very different tempo and mode of sequence evolution than star products. We establish a new open access database -- MirGeneDB ( http://mirgenedb.org) -- to catalog this set of robustly supported miRNAs, which complements the efforts of miRBase, but differs from it by annotating the mature versus star products, and by imposing an evolutionary hierarchy upon this curated and consistently named repertoire.

          Related collections

          Author and article information

          Journal
          0117605
          668
          Annu Rev Genet
          Annu. Rev. Genet.
          Annual review of genetics
          0066-4197
          1545-2948
          28 January 2016
          14 October 2015
          23 November 2015
          23 November 2016
          : 49
          : 213-242
          Affiliations
          [1 ]Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, PO Box 4950, Nydalen, N-0424 Oslo, Norway
          [2 ]Department of Biological Sciences, Dartmouth College, Hanover NH 03755 USA
          [3 ]Department of Biology and Health Sciences, New England College, Henniker NH 03242 USA
          [4 ]Genome Evolution Laboratory, Department of Biology, The National University of Ireland, Maynooth, Kildare, Ireland
          [5 ]School of Earth Sciences, University of Bristol, BS8 1TQ Bristol, UK
          [6 ]Kathryn W. Davis Center for Regenerative Biology and Medicine, Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672 USA
          [7 ]Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503 USA
          [8 ]Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway
          [9 ]Department of Gastroenterological Surgery, The Norwegian Radium Hospital, Oslo University Hospital, PO Box 4950, Nydalen, N-0424 Oslo, Norway
          [10 ]Institute of Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway
          [11 ]Department of Informatics, University of Oslo, PO Box 1080 Blindern, N-0316 Oslo, Norway
          Author notes
          [* ]Author for Correspondence: Kevin J. Peterson, Department of Biological Sciences Dartmouth College, Hanover NH 03755 USA 603-646-0215 (v), kevin.j.peterson@ 123456dartmouth.edu
          Article
          PMC4743252 PMC4743252 4743252 nihpa754425
          10.1146/annurev-genet-120213-092023
          4743252
          26473382
          e5468be1-c10c-49bf-8e46-4179e89bad90
          Categories
          Article

          MirGeneDB.org,miRNA,molecular evolution,vertebrate,genome duplication,miRBase

          Comments

          Comment on this article