+1 Recommend
1 collections
      Are you tired of sifting through news that doesn't interest you?
      Personalize your Karger newsletter today and get only the news that matters to you!

      Sign up

      • Record: found
      • Abstract: found
      • Article: found

      Topically Induced Ocular Anaphylaxis in Rats Immunized with Egg Albumin


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          A model of topically induced ocular anaphylaxis was developed. Male Sprague-Dawley rats were immunized by intraperitoneal injections of egg albumin (EA) and alum and topically challenged with EA. Application of EA induced clinical (conjunctival edema) and histologic (mast cell degranulation) signs of anaphylaxis, when the antigen was preceded by topical application of dithiothreitol (DTT), a mucolytic agent. Rats challenged by four EA applications did not differ significantly in clinical edema or mast cell degranulation from those challenged by one EA application at the same (0.1 M DTT) pretreatment level, but there was significantly greater histologically assessed edema in the eyes challenged four times.

          Related collections

          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          04 December 2009
          : 18
          : 2
          : 68-74
          aEye Research Institute of Retina Foundation, bForsyth Dental Center, Departments ofc Medicine and dOphthalmology, Harvard Medical School, and cClinical Immunology and Allergy Units, Massachusetts General Hospital, Boston, Mass., USA
          265417 Ophthalmic Res 1986;18:68–74
          © 1986 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 08 August 1985
          : 28 August 1985
          Page count
          Pages: 7
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Anaphylaxis,Mast cell,Ocular,Allergy,Conjunctiva,Topical,Antigen


          Comment on this article