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      Topically Induced Ocular Anaphylaxis in Rats Immunized with Egg Albumin

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          Abstract

          A model of topically induced ocular anaphylaxis was developed. Male Sprague-Dawley rats were immunized by intraperitoneal injections of egg albumin (EA) and alum and topically challenged with EA. Application of EA induced clinical (conjunctival edema) and histologic (mast cell degranulation) signs of anaphylaxis, when the antigen was preceded by topical application of dithiothreitol (DTT), a mucolytic agent. Rats challenged by four EA applications did not differ significantly in clinical edema or mast cell degranulation from those challenged by one EA application at the same (0.1 M DTT) pretreatment level, but there was significantly greater histologically assessed edema in the eyes challenged four times.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1986
          1986
          04 December 2009
          : 18
          : 2
          : 68-74
          Affiliations
          aEye Research Institute of Retina Foundation, bForsyth Dental Center, Departments ofc Medicine and dOphthalmology, Harvard Medical School, and cClinical Immunology and Allergy Units, Massachusetts General Hospital, Boston, Mass., USA
          Article
          265417 Ophthalmic Res 1986;18:68–74
          10.1159/000265417
          3737114
          © 1986 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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