Generation of urine iPS cell lines from patients with Attention Deficit Hyperactivity Disorder (ADHD) using a non-integrative method.

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Abstract

Urine samples were collected from three patients (2 males, 1 female) with clinically diagnosed Attention Deficit Hyperactivity Disorder (ADHD) according to DSM-5 criteria using semi-structured interviews (K-SADS adapted for adults) by a trained psychiatrist. Urine epithelial cell lines were established and expanded for subsequent reprogramming procedure. Induced pluripotent stem cells (iPSCs) were derived using integration-free CytoTune®-iPS 2.0 Sendai Reprogramming Kit, which includes Sendai virus particles of the four Yamanaka factors Oct3/4, Sox2, Klf4 and c-Myc.

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Author and article information

Journal

Journal ID (iso-abbrev): Stem Cell Res

Title: Stem cell research

Publisher: Elsevier BV

ISSN (Electronic): 1876-7753

ISSN (Print): 1873-5061

Publication date (Electronic): May 27 2016

Volume: 17

Issue: 1

Affiliations

[1 ] D'Or Institute for Research and Education (IDOR), Rua Diniz Cordeiro, 30, Rio de Janeiro 222281, Brazil.

[2 ] D'Or Institute for Research and Education (IDOR), Rua Diniz Cordeiro, 30, Rio de Janeiro 222281, Brazil; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Avenida Carlos Chagas, 373, Rio de Janeiro 21941, Brazil. Electronic address: srehen@lance-ufrj.org.

Article

Publisher Item ID: S1873-5061(16)30056-3

DOI: 10.1016/j.scr.2016.05.015

PubMed ID: 27558611

SO-VID: e5536687-2d5e-486f-b751-c037d5f66297

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