Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy.

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Abstract

Spermidine is an endogenous biological polyamine that exhibits broad longevity-extending activities via the induction of autophagy. Because basal autophagy is atheroprotective during early atherosclerosis but dysfunctional in advanced plaques, the aim of the present study was to assess the potential beneficial effects of autophagy induction by spermidine on atherosclerotic plaque progression and composition.

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Journal

Journal ID (iso-abbrev): Atherosclerosis

Title: Atherosclerosis

Publisher: Elsevier BV

ISSN (Electronic): 1879-1484

ISSN (Print): 0021-9150

Publication date (Electronic): Aug 2016

Volume: 251

Affiliations

[1 ] Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.

[2 ] Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.

[3 ] Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium. Electronic address: wim.martinet@uantwerpen.be.

Article

Publisher Item ID: S0021-9150(16)31200-X

DOI: 10.1016/j.atherosclerosis.2016.07.899

PubMed ID: 27450786

SO-VID: e5588e13-5ba3-4576-8499-8344785de160

History

Keywords: Atherosclerosis,Autophagy,Cholesterol efflux,Necrosis,Spermidine

Data availability:

Keywords: Atherosclerosis, Autophagy, Cholesterol efflux, Necrosis, Spermidine

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Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy.

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