Maturity-onset diabetes of the young type 3 and premature ovarian insufficiency: chance or causality: a case report and literature review

Abstract

Summary

We present the case of a 23-year-old patient with maturity-onset diabetes of the young type 3 (MODY 3) and premature ovarian insufficiency (POI). There is no known correlation between MODY 3 and POI, although POI can impair glucose metabolism, and MODY can cause microvascular complications such as POI. We did not find literature describing a correlation between these two pathologies nor did we find similar cases described in the literature.

Learning points

• Maturity-onset diabetes of the young type 3 (MODY 3) is an infrequent cause of diabetes that should be considered in young patients with atypical presentation of type 1 or type 2 diabetes.

• MODY 3 can be associated with microvascular complications of diabetes, which is why it is important to diagnose as early as possible.

• Impairment of glucose metabolism has been demonstrated in patients with premature ovarian insufficiency and menopause.