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      Linezolid-induced lactic acidosis corrected with sustained low-efficiency dialysis: a case report.

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          Abstract

          Linezolid, an oxazolidinone antibiotic, has been reported to increase the risk of lactic acidosis and peripheral neuropathy because it disrupts mitochondrial function. This case report describes the development of lactic acidosis in a 63-year-old man who had received 3 months of treatment with intravenous linezolid for pulmonary nocardiasis, and correction of the acidotic state with sustained low-efficiency dialysis. This case demonstrates that renal replacement therapy can be an alternative to discontinuation alone for rapid reversal of linezolid-induced lactic acidosis.

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          Author and article information

          Journal
          Am. J. Kidney Dis.
          American journal of kidney diseases : the official journal of the National Kidney Foundation
          Elsevier BV
          1523-6838
          0272-6386
          Sep 2014
          : 64
          : 3
          Affiliations
          [1 ] Huntsville Hospital, Huntsville, AL. Electronic address: adam.sawyer@hhsys.org.
          [2 ] Huntsville Hospital, Huntsville, AL. Electronic address: haley0513@gmail.com.
          [3 ] Huntsville Hospital, Huntsville, AL.
          Article
          S0272-6386(14)00892-0
          10.1053/j.ajkd.2014.04.032
          24961626

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